| Literature DB >> 26463755 |
Faustin A Kabran1, Timothée A Okpekon2, François Roblot3, Blandine Séon-Méniel3, Karine Leblanc3, Christian Bories4, Pierre Champy3, Séri F Yolou5, Philippe M Loiseau4, Léon A Djakouré2, Bruno Figadère3, Alexandre Maciuk6.
Abstract
The two new acylphloroglucinol derivatives, methylene-bis-aspidinol AB (1) and mallopposinol (2), together with the nine known compounds, aspidinol B (3), methylene-bis-aspidinol (4), (+)-α-tocopherol (5), lupeol (6), stigmasterol (7), phytol (8), bergenin (9), squalene (11) and methyl gallate (10) were isolated from the leaves of Mallotus oppositifolius. Their structures were elucidated by spectral analysis including MS, 1D and 2D-NMR spectroscopy. In vitro trypanocidal and antileishmanial activities of compounds 1-9 were evaluated. Mallopposinol (2) and aspidinol B (3) displayed weak antileishmanial activities against Leishmania donovani promastigotes, with EC50 values of 21.3 and 38.8μM, respectively. Only the methylene-bis-aspidinol (4) exhibited trypanocidal activity against Trypanosoma brucei brucei trypomastigotes (LC100=0.8μM) similar to the reference drug pentamidine (LC100=0.4μM).Entities:
Keywords: (+)-tocophérol (PubChem CID: 14985); Aspidinol B (PubChem CID: 122841); Euphorbiaceae; Leishmania donovani; Mallotus oppositifolius; Methylene-bis-aspidinol (PubChem CID: 617027); Phloroglucinol; Trypanosoma brucei brucei; bergenin (PubChem CID: 66065); lupeol (PubChem CID: 259846); methyl gallate (PubChem CID: 7428); phytol (PubChem CID: 5280435); squalene (PubChem CID: 638072); stigmasterol (PubChem CID: 5280794)
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Year: 2015 PMID： 26463755 DOI： 10.1016/j.fitote.2015.09.015
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882