Literature DB >> 26463714

Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E Samuels1, Avraham Eisbruch1, Jonathan J Beitler2, June Corry3, Carol R Bradford4, Nabil F Saba5, Michiel W M van den Brekel6, Robert Smee7, Primož Strojan8, Carlos Suárez9,10, William M Mendenhall11, Robert P Takes12, Juan P Rodrigo9,10, Missak Haigentz13, Alexander D Rapidis14, Alessandra Rinaldo15, Alfio Ferlito16.   

Abstract

HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV-) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

Entities:  

Keywords:  Cetuximab; EGFR; HPV; Hypoxia; Oropharyngeal carcinoma; Radiosensitivity; TORS; Treatment de-intensification; p16

Mesh：

Substances：

Year:  2015        PMID： 26463714     DOI： 10.1007/s00405-015-3771-x

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   3.236


  165 in total

1.  A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy.

Authors:  B G Wouters; N C Denko; A J Giaccia; J M Brown
Journal:  Oncogene       Date:  1999-11-11       Impact factor: 9.867

2.  The comparison of weekly and three-weekly cisplatin chemotherapy concurrent with radiotherapy in patients with previously untreated inoperable non-metastatic squamous cell carcinoma of the head and neck.

Authors:  Kazim Uygun; Ahmet Bilici; Hakan Karagol; Murat Caloglu; Irfan Cicin; Gorkem Aksu; Merdan Fayda; Sernaz Uzunoglu
Journal:  Cancer Chemother Pharmacol       Date:  2009-01-03       Impact factor: 3.333

3.  Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer.

Authors:  Daniel W Vermeer; William C Spanos; Paola D Vermeer; Annie M Bruns; Kimberly M Lee; John H Lee
Journal:  Int J Cancer       Date:  2013-02-12       Impact factor: 7.396

4.  Calreticulin exposure dictates the immunogenicity of cancer cell death.

Authors:  Michel Obeid; Antoine Tesniere; François Ghiringhelli; Gian Maria Fimia; Lionel Apetoh; Jean-Luc Perfettini; Maria Castedo; Grégoire Mignot; Theoharis Panaretakis; Noelia Casares; Didier Métivier; Nathanael Larochette; Peter van Endert; Fabiola Ciccosanti; Mauro Piacentini; Laurence Zitvogel; Guido Kroemer
Journal:  Nat Med       Date:  2006-12-24       Impact factor: 53.440

5.  Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status.

Authors:  Jessica H Maxwell; Robert L Ferris; William Gooding; Diana Cunningham; Vikas Mehta; Seungwon Kim; Eugene N Myers; Jonas Johnson; Simion Chiosea
Journal:  Cancer       Date:  2013-06-24       Impact factor: 6.860

6.  E1308: Phase II Trial of Induction Chemotherapy Followed by Reduced-Dose Radiation and Weekly Cetuximab in Patients With HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx- ECOG-ACRIN Cancer Research Group.

Authors:  Shanthi Marur; Shuli Li; Anthony J Cmelak; Maura L Gillison; Weiqiang J Zhao; Robert L Ferris; William H Westra; Jill Gilbert; Julie E Bauman; Lynne I Wagner; David R Trevarthen; Jahagirdar Balkrishna; Barbara A Murphy; Nishant Agrawal; A Dimitrios Colevas; Christine H Chung; Barbara Burtness
Journal:  J Clin Oncol       Date:  2016-12-28       Impact factor: 44.544

7.  De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials.

Authors:  Liam Masterson; Daniel Moualed; Zi Wei Liu; James E F Howard; Raghav C Dwivedi; James R Tysome; Richard Benson; Jane C Sterling; Holger Sudhoff; Piyush Jani; Peter K C Goon
Journal:  Eur J Cancer       Date:  2014-08-01       Impact factor: 9.162

8.  Correlation of p16 status, hypoxic imaging using [18F]-misonidazole positron emission tomography and outcome in patients with loco-regionally advanced head and neck cancer.

Authors:  Mateya E Trinkaus; Rodney J Hicks; Richard J Young; Lester J Peters; Ben Solomon; Mathias Bressel; June Corry; Richard Fisher; David Binns; Grant A McArthur; Danny Rischin
Journal:  J Med Imaging Radiat Oncol       Date:  2014-02       Impact factor: 1.735

Review 9.  HPV-induced oropharyngeal cancer, immune response and response to therapy.

Authors:  Ha Linh Vu; Andrew G Sikora; Shibo Fu; Johnny Kao
Journal:  Cancer Lett       Date:  2009-07-22       Impact factor: 8.679

10.  Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells.

Authors:  B Sauter; M L Albert; L Francisco; M Larsson; S Somersan; N Bhardwaj
Journal:  J Exp Med       Date:  2000-02-07       Impact factor: 14.307
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  6 in total

Review 1.  [Human papillomavirus and squamous cell cancer of the head and neck region : Prognostic, therapeutic and prophylactic implications].

Authors:  M Reuschenbach; S Wagner; N Würdemann; S J Sharma; E-S Prigge; M Sauer; A Wittig; C Wittekindt; M von Knebel Doeberitz; J P Klussmann
Journal:  HNO       Date:  2016-07       Impact factor: 1.284

2.  Characterizing CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy.

Authors:  A Makkouk; V Sundaram; C Chester; S Chang; A D Colevas; J B Sunwoo; H Maecker; M Desai; H E Kohrt
Journal:  Ann Oncol       Date:  2017-02-01       Impact factor: 32.976

3.  The Role of Adjuvant Chemotherapy in Surgically Managed, p16-Positive Oropharyngeal Squamous Cell Carcinoma.

Authors:  S Andrew Skillington; Dorina Kallogjeri; James S Lewis; Jay F Piccirillo
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2017-03-01       Impact factor: 6.223

4.  Comparisons of dysphagia and quality of life (QOL) in comparable patients with HPV-positive oropharyngeal cancer receiving chemo-irradiation or cetuximab-irradiation.

Authors:  Stuart E Samuels; Yebin Tao; Teresa Lyden; Marc Haxer; Matthew Spector; Kelly M Malloy; Mark E Prince; Carol R Bradford; Francis P Worden; Matthew Schipper; Avraham Eisbruch
Journal:  Oral Oncol       Date:  2016-01-06       Impact factor: 5.337

5.  Laryngeal Squamous Cell Carcinoma Survival in the Context of Human Papillomavirus: A Systematic Review and Meta-analysis.

Authors:  Navid Ahmadi; Nima Ahmadi; Michael V Chan; Ya Ruth Huo; Niranjan Sritharan; Ronald Chin
Journal:  Cureus       Date:  2018-02-26

Review 6.  Molecular mechanisms underlying increased radiosensitivity in human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Authors:  Huanhuan Wang; Bin Wang; Jinlong Wei; Lingbin Meng; Qihe Zhang; Chao Qu; Ying Xin; Xin Jiang
Journal:  Int J Biol Sci       Date:  2020-02-04       Impact factor: 6.580
  6 in total

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