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Literature DB >> 26463662

Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha.

Jin Hu¹, Guilin Wang¹, Xinyu Liu¹, Weiping Gao¹.

Abstract

Genetic fusion of elastin-like polypeptide (ELP) to the C-terminus of interferon alpha (IFN) generates a well-defined IFN-ELP fusion protein with high yield and well-retained bioactivity. The fusion protein significantly enhances pharmacokinetics, tumor accumulation, and antitumor efficacy of interferon alpha in a murine cancer model.

Entities: Disease Gene Species

Keywords: cancer therapy; elastin-like polypeptides; interferon; pharmacokinetics; protein delivery

Mesh：

Substances：

Year: 2015 PMID： 26463662 DOI： 10.1002/adma.201503440

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

7 in total

1. B₁₂-dependent photoresponsive protein hydrogels for controlled stem cell/protein release.

Authors: Ri Wang; Zhongguang Yang; Jiren Luo; I-Ming Hsing; Fei Sun
Journal: Proc Natl Acad Sci U S A Date: 2017-05-22 Impact factor: 11.205

2. Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity.

Authors: Jun Yin; Lichen Bao; Hong Tian; Qun Wang; Xiangdong Gao; Wenbing Yao
Journal: Br J Pharmacol Date: 2016-06-03 Impact factor: 8.739

Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha.

1. B₁₂-dependent photoresponsive protein hydrogels for controlled stem cell/protein release.

2. Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity.

3. Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking.

Review 4. Interferon and Hepatitis B: Current and Future Perspectives.

Review 5. Genetically engineered materials: Proteins and beyond.

Review 6. Application of Elastin-like Polypeptide in Tumor Therapy.

7. Protection of Ducklings from Duck Hepatitis A Virus Infection with ELPylated Duck Interferon-α.

Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha.

1. B12-dependent photoresponsive protein hydrogels for controlled stem cell/protein release.

2. Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity.

3. Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking.

Review 4. Interferon and Hepatitis B: Current and Future Perspectives.

Review 5. Genetically engineered materials: Proteins and beyond.

Review 6. Application of Elastin-like Polypeptide in Tumor Therapy.

7. Protection of Ducklings from Duck Hepatitis A Virus Infection with ELPylated Duck Interferon-α.

1. B₁₂-dependent photoresponsive protein hydrogels for controlled stem cell/protein release.