L De Santiago1, M Ortiz Del Castillo1, R Blanco2, R Barea1, J M Rodríguez-Ascariz1, J M Miguel-Jiménez1, E M Sánchez-Morla3, L Boquete4. 1. Biomedical Engineering Research Group, Department of Electronics, University of Alcalá, Plaza de S. Diego, s/n, 28801 Alcalá de Henares, Spain; Department of Electronics, University of Alcalá, Plaza de S. Diego, s/n, 28801 Alcalá de Henares, Spain. 2. Department of Surgery and Medical Sciences, University of Alcalá, Plaza de S. Diego, s/n, 28801 Alcalá de Henares, Spain. 3. Department of Psychiatry, University Hospital of Guadalajara, Spain. 4. Biomedical Engineering Research Group, Department of Electronics, University of Alcalá, Plaza de S. Diego, s/n, 28801 Alcalá de Henares, Spain; Department of Electronics, University of Alcalá, Plaza de S. Diego, s/n, 28801 Alcalá de Henares, Spain. Electronic address: luciano.boquete@uah.es.
Abstract
OBJECTIVE: To study the value of using the signal-to-noise ratio (SNR) of multifocal visual-evoked potentials (mfVEPs) in assessment of subjects at risk of developing multiple sclerosis (MS). METHODS: MfVEP signals were obtained from 15 patients with radiologically isolated syndrome (RIS), from 28 patients with clinically isolated syndrome (CIS), from 28 with clinically definite MS and from 24 control subjects. The CIS and MS groups were divided into two subgroups: those with eyes affected by optic neuritis (ON) and those without (non-ON). The mfVEPs' SNR was obtained for both the whole visual field and at various eccentric rings. The area under the curve (AUC) was calculated by comparing the control subjects' mfVEP SNR values with those of the RIS, CIS and MS groups. RESULTS: In whole visual field analysis, risk of developing MS increased as SNR decreased (SNRCONTROL=0.70, SNRRIS=0.62, SNRCIS-nonON=0.54, SNRCIS-ON=0.40, SNRMS-nonON=0.52, SNRMS-ON=0.40). Ring 5 (9.8°-15° eccentricity) was most affected by the SNR decrease, as indicated by its higher AUC values (AUCFULL_EYE=0.81, AUCRING_5=0.89). A significant relationship (Spearman correlation, ρRING_5=0.61) between SNR values and disability severity on the Expanded Disability Status Scale (EDSS) was observed in clinically definite MS patients. CONCLUSION: A new method based on analysis of the SNR of mfVEP signal amplitude improves assessment of patients at risk of developing MS. SIGNIFICANCE: Improved mfVEP assessment of MS-risk patients was achieved by using SNR values at 9.8°-15° eccentricity of the visual field.
OBJECTIVE: To study the value of using the signal-to-noise ratio (SNR) of multifocal visual-evoked potentials (mfVEPs) in assessment of subjects at risk of developing multiple sclerosis (MS). METHODS: MfVEP signals were obtained from 15 patients with radiologically isolated syndrome (RIS), from 28 patients with clinically isolated syndrome (CIS), from 28 with clinically definite MS and from 24 control subjects. The CIS and MS groups were divided into two subgroups: those with eyes affected by optic neuritis (ON) and those without (non-ON). The mfVEPs' SNR was obtained for both the whole visual field and at various eccentric rings. The area under the curve (AUC) was calculated by comparing the control subjects' mfVEP SNR values with those of the RIS, CIS and MS groups. RESULTS: In whole visual field analysis, risk of developing MS increased as SNR decreased (SNRCONTROL=0.70, SNRRIS=0.62, SNRCIS-nonON=0.54, SNRCIS-ON=0.40, SNRMS-nonON=0.52, SNRMS-ON=0.40). Ring 5 (9.8°-15° eccentricity) was most affected by the SNR decrease, as indicated by its higher AUC values (AUCFULL_EYE=0.81, AUCRING_5=0.89). A significant relationship (Spearman correlation, ρRING_5=0.61) between SNR values and disability severity on the Expanded Disability Status Scale (EDSS) was observed in clinically definite MS patients. CONCLUSION: A new method based on analysis of the SNR of mfVEP signal amplitude improves assessment of patients at risk of developing MS. SIGNIFICANCE: Improved mfVEP assessment of MS-risk patients was achieved by using SNR values at 9.8°-15° eccentricity of the visual field.
Authors: M Ortiz Del Castillo; B Cordón; E M Sánchez Morla; E Vilades; M J Rodrigo; C Cavaliere; L Boquete; E Garcia-Martin Journal: Doc Ophthalmol Date: 2019-09-19 Impact factor: 2.379
Authors: Luis de Santiago; Eva Sánchez-Morla; Román Blanco; Juan Manuel Miguel; Carlos Amo; Miguel Ortiz Del Castillo; Almudena López; Luciano Boquete Journal: PLoS One Date: 2018-04-20 Impact factor: 3.240
Authors: Luis de Santiago; E M Sánchez Morla; Miguel Ortiz; Elena López; Carlos Amo Usanos; M C Alonso-Rodríguez; R Barea; Carlo Cavaliere-Ballesta; Alfredo Fernández; Luciano Boquete Journal: PLoS One Date: 2019-04-04 Impact factor: 3.240