Literature DB >> 26463248

Biologic Therapy in Immune Mediated Inflammatory Disease: Basic Science and Clinical Concepts.

E Molinelli1, A Campanati, G Ganzetti, A Offidani.   

Abstract

During the last decades, the advent of biological therapies has revolutionized the management of several immune-mediated inflammatory disorders, as inflammatory bowel diseases, autoimmune arthritis and psoriasis, which significantly impact both quality of life and health care economics. Biological therapies currently available can be divided into two main categories: the tumor necrosis factor-α antagonists (infliximab, adalimumab, etanercept, golimumab, certolizumab pegol) and interleukin 12/23 monoclonal antibodies (ustekinumab). Biologics, reducing TNFα bioavailability or inhibiting proximal regulators of inflammatory cascade, represent an established therapeutic strategy of inflammatory autoimmune diseases, with remarkable efficacy and a safety profile that is extensively examined and monitored. The biology and the immunological effects of TNFα, IL-12, IL-23 and related signalling pathways are accurately summarized. The dosing regimens, methods of administration, pharmacodynamics profiles, and side effects of the currently licensed TNFα antagonists and IL12/IL23 inhibitor are discussed in detail.

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Year:  2016        PMID： 26463248     DOI： 10.2174/1574886310666151014115127

Source DB:  PubMed          Journal:  Curr Drug Saf        ISSN： 1574-8863


  9 in total

1.  [Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy : Data from a nationwide German registry (GRAID2)].

Authors:  F Proft; H Schulze-Koops; M Grunke; E Schrezenmeier; F Halleck; J Henes; L Unger; E Schmidt; C Fiehn; A Jacobi; C Iking-Konert; C Kneitz; R E Schmidt; B Bannert; R E Voll; R Fischer-Betz; I Kötter; H P Tony; J Holle; M Aringer; A Erler; F Behrens; G R Burmester; T Dörner
Journal:  Z Rheumatol       Date:  2018-02       Impact factor: 1.372

2.  The structure-function relationship of disulfide bonds in etanercept.

Authors:  William C Lamanna; Robert Ernst Mayer; Alfred Rupprechter; Michael Fuchs; Fabian Higel; Cornelius Fritsch; Cornelia Vogelsang; Andreas Seidl; Hansjoerg Toll; Martin Schiestl; Johann Holzmann
Journal:  Sci Rep       Date:  2017-06-21       Impact factor: 4.379

3.  Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Authors:  Anne E Justice; Tugce Karaderi; Heather M Highland; Kristin L Young; Mariaelisa Graff; Yingchang Lu; Valérie Turcot; L Adrienne Cupples; Ruth J F Loos; Kari E North; Cecilia M Lindgren; Paul L Auer; Rebecca S Fine; Xiuqing Guo; Claudia Schurmann; Adelheid Lempradl; Eirini Marouli; Anubha Mahajan; Thomas W Winkler; Adam E Locke; Carolina Medina-Gomez; Tõnu Esko; Sailaja Vedantam; Ayush Giri; Ken Sin Lo; Tamuno Alfred; Poorva Mudgal; Maggie C Y Ng; Nancy L Heard-Costa; Mary F Feitosa; Alisa K Manning; Sara M Willems; Suthesh Sivapalaratnam; Goncalo Abecasis; Dewan S Alam; Matthew Allison; Philippe Amouyel; Zorayr Arzumanyan; Beverley Balkau; Lisa Bastarache; Sven Bergmann; Lawrence F Bielak; Matthias Blüher; Michael Boehnke; Heiner Boeing; Eric Boerwinkle; Carsten A Böger; Jette Bork-Jensen; Erwin P Bottinger; Donald W Bowden; Ivan Brandslund; Linda Broer; Amber A Burt; Adam S Butterworth; Mark J Caulfield; Giancarlo Cesana; John C Chambers; Daniel I Chasman; Yii-Der Ida Chen; Rajiv Chowdhury; Cramer Christensen; Audrey Y Chu; Francis S Collins; James P Cook; Amanda J Cox; David S Crosslin; John Danesh; Paul I W de Bakker; Simon de Denus; Renée de Mutsert; George Dedoussis; Ellen W Demerath; Joe G Dennis; Josh C Denny; Emanuele Di Angelantonio; Marcus Dörr; Fotios Drenos; Marie-Pierre Dubé; Alison M Dunning; Douglas F Easton; Paul Elliott; Evangelos Evangelou; Aliki-Eleni Farmaki; Shuang Feng; Ele Ferrannini; Jean Ferrieres; Jose C Florez; Myriam Fornage; Caroline S Fox; Paul W Franks; Nele Friedrich; Wei Gan; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Giorgia Girotto; Mathias Gorski; Harald Grallert; Niels Grarup; Megan L Grove; Stefan Gustafsson; Jeff Haessler; Torben Hansen; Andrew T Hattersley; Caroline Hayward; Iris M Heid; Oddgeir L Holmen; G Kees Hovingh; Joanna M M Howson; Yao Hu; Yi-Jen Hung; Kristian Hveem; M Arfan Ikram; Erik Ingelsson; Anne U Jackson; Gail P Jarvik; Yucheng Jia; Torben Jørgensen; Pekka Jousilahti; Johanne M Justesen; Bratati Kahali; Maria Karaleftheri; Sharon L R Kardia; Fredrik Karpe; Frank Kee; Hidetoshi Kitajima; Pirjo Komulainen; Jaspal S Kooner; Peter Kovacs; Bernhard K Krämer; Kari Kuulasmaa; Johanna Kuusisto; Markku Laakso; Timo A Lakka; David Lamparter; Leslie A Lange; Claudia Langenberg; Eric B Larson; Nanette R Lee; Wen-Jane Lee; Terho Lehtimäki; Cora E Lewis; Huaixing Li; Jin Li; Ruifang Li-Gao; Li-An Lin; Xu Lin; Lars Lind; Jaana Lindström; Allan Linneberg; Ching-Ti Liu; Dajiang J Liu; Jian'an Luan; Leo-Pekka Lyytikäinen; Stuart MacGregor; Reedik Mägi; Satu Männistö; Gaëlle Marenne; Jonathan Marten; Nicholas G D Masca; Mark I McCarthy; Karina Meidtner; Evelin Mihailov; Leena Moilanen; Marie Moitry; Dennis O Mook-Kanamori; Anna Morgan; Andrew P Morris; Martina Müller-Nurasyid; Patricia B Munroe; Narisu Narisu; Christopher P Nelson; Matt Neville; Ioanna Ntalla; Jeffrey R O'Connell; Katharine R Owen; Oluf Pedersen; Gina M Peloso; Craig E Pennell; Markus Perola; James A Perry; John R B Perry; Tune H Pers; Ailith Ewing; Ozren Polasek; Olli T Raitakari; Asif Rasheed; Chelsea K Raulerson; Rainer Rauramaa; Dermot F Reilly; Alex P Reiner; Paul M Ridker; Manuel A Rivas; Neil R Robertson; Antonietta Robino; Igor Rudan; Katherine S Ruth; Danish Saleheen; Veikko Salomaa; Nilesh J Samani; Pamela J Schreiner; Matthias B Schulze; Robert A Scott; Marcelo Segura-Lepe; Xueling Sim; Andrew J Slater; Kerrin S Small; Blair H Smith; Jennifer A Smith; Lorraine Southam; Timothy D Spector; Elizabeth K Speliotes; Kari Stefansson; Valgerdur Steinthorsdottir; Kathleen E Stirrups; Konstantin Strauch; Heather M Stringham; Michael Stumvoll; Liang Sun; Praveen Surendran; Karin M A Swart; Jean-Claude Tardif; Kent D Taylor; Alexander Teumer; Deborah J Thompson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Betina H Thuesen; Anke Tönjes; Mina Torres; Emmanouil Tsafantakis; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; Cornelia M van Duijn; Mauno Vanhala; Rohit Varma; Sita H Vermeulen; Henrik Vestergaard; Veronique Vitart; Thomas F Vogt; Dragana Vuckovic; Lynne E Wagenknecht; Mark Walker; Lars Wallentin; Feijie Wang; Carol A Wang; Shuai Wang; Nicholas J Wareham; Helen R Warren; Dawn M Waterworth; Jennifer Wessel; Harvey D White; Cristen J Willer; James G Wilson; Andrew R Wood; Ying Wu; Hanieh Yaghootkar; Jie Yao; Laura M Yerges-Armstrong; Robin Young; Eleftheria Zeggini; Xiaowei Zhan; Weihua Zhang; Jing Hua Zhao; Wei Zhao; He Zheng; Wei Zhou; M Carola Zillikens; Fernando Rivadeneira; Ingrid B Borecki; J Andrew Pospisilik; Panos Deloukas; Timothy M Frayling; Guillaume Lettre; Karen L Mohlke; Jerome I Rotter; Zoltán Kutalik; Joel N Hirschhorn
Journal:  Nat Genet       Date:  2019-02-18       Impact factor: 38.330

4.  Safety of Ixekizumab in Patients With Psoriatic Arthritis: Results From a Pooled Analysis of Three Clinical Trials.

Authors:  Philip Mease; Euthalia Roussou; Gerd-Rüdiger Burmester; Philippe Goupille; Alice Gottlieb; Susan R Moriarty; Olivier Benichou; David H Adams; Wen Xu; Peter Nash
Journal:  Arthritis Care Res (Hoboken)       Date:  2019-02-12       Impact factor: 4.794

5.  Design and implementation of a mobile app for the pharmacotherapeutic follow-up of patients diagnosed with immune-mediated inflammatory diseases: eMidCare.

Authors:  Rosa Romero-Jimenez; Vicente Escudero-Vilaplana; Esther Chamorro-de-Vega; Arantza Ais-Larisgoitia; Elena Lobato-Matilla; Beatriz Somoza-Fernández; Paula Ruiz-Briones; Carlos González; Ofelia Baniandrés; Luis Menchén; Carmen Lobo-Rodríguez; Ana Herranz; María Sanjurjo
Journal:  Front Immunol       Date:  2022-07-28       Impact factor: 8.786

6.  "Biosimilar, so it looks alike, but what does it mean?" A qualitative study of Danish patients' perceptions of biosimilars.

Authors:  Meera Varma; Anna Birna Almarsdóttir; Louise C Druedahl
Journal:  Basic Clin Pharmacol Toxicol       Date:  2022-03-15       Impact factor: 3.688

7.  Therapeutic application of PPE2 protein of Mycobacterium tuberculosis in inhibiting tissue inflammation.

Authors:  Ravi Pal; Madhu Babu Battu; Sangita Mukhopadhyay
Journal:  EMBO Mol Med       Date:  2022-07-11       Impact factor: 14.260

Review 8.  Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives.

Authors:  Silvia Lucia Appleton; Silvia Navarro-Orcajada; Francisco Juan Martínez-Navarro; Fabrizio Caldera; José Manuel López-Nicolás; Francesco Trotta; Adrián Matencio
Journal:  Biomolecules       Date:  2021-09-19

Review 9.  Impact of Pharmacokinetic and Pharmacodynamic Properties of Monoclonal Antibodies in the Management of Psoriasis.

Authors:  Karine Rodríguez-Fernández; Víctor Mangas-Sanjuán; Matilde Merino-Sanjuán; Antonio Martorell-Calatayud; Almudena Mateu-Puchades; Mónica Climente-Martí; Elena Gras-Colomer
Journal:  Pharmaceutics       Date:  2022-03-16       Impact factor: 6.321
  9 in total

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