Literature DB >> 26462973

The copper binding properties of metformin--QCM-D, XPS and nanobead agglomeration.

Xueling Quan1, Rokon Uddin1, Arto Heiskanen1, Mattias Parmvi1, Katharina Nilson2, Marco Donolato1, Mikkel F Hansen1, Graham Rena3, Anja Boisen1.   

Abstract

Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine-copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.

Entities:  

Year:  2015        PMID： 26462973     DOI： 10.1039/c5cc04321b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Authors:  Amy R Cameron; Vicky L Morrison; Daniel Levin; Mohapradeep Mohan; Calum Forteath; Craig Beall; Alison D McNeilly; David J K Balfour; Terhi Savinko; Aaron K F Wong; Benoit Viollet; Kei Sakamoto; Susanna C Fagerholm; Marc Foretz; Chim C Lang; Graham Rena
Journal:  Circ Res       Date:  2016-07-14       Impact factor: 17.367

2.  Metformin selectively targets redox control of complex I energy transduction.

Authors:  Amy R Cameron; Lisa Logie; Kashyap Patel; Stefan Erhardt; Sandra Bacon; Paul Middleton; Jean Harthill; Calum Forteath; Josh T Coats; Calum Kerr; Heather Curry; Derek Stewart; Kei Sakamoto; Peter Repiščák; Martin J Paterson; Ilmo Hassinen; Gordon McDougall; Graham Rena
Journal:  Redox Biol       Date:  2017-08-26       Impact factor: 11.799

Review 3.  To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents.

Authors:  Isaac Arbeláez-Quintero; Mauricio Palacios
Journal:  Stroke Res Treat       Date:  2017-05-28

4.  Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.

Authors:  Traci E LaMoia; Gina M Butrico; Hasini A Kalpage; Leigh Goedeke; Brandon T Hubbard; Daniel F Vatner; Rafael C Gaspar; Xian-Man Zhang; Gary W Cline; Keita Nakahara; Seungwan Woo; Atsuhiro Shimada; Maik Hüttemann; Gerald I Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-01       Impact factor: 12.779

5.  Synthesis and Characterization of the Nanogold-Bound Ternary Copper(II) Complex of Phenanthroline and Cysteine as Potential Anticancer Agents.

Authors:  Ahmad Junaid; Chew Hee Ng; Ing Hong Ooi
Journal:  ACS Omega       Date:  2022-07-19

6.  Water-Soluble Gold(III)-Metformin Complex Alters Mitochondrial Bioenergetics in Breast Cancer Cells.

Authors:  Jong Hyun Kim; Samuel Ofori; R Tyler Mertens; Sean Parkin; Samuel G Awuah
Journal:  ChemMedChem       Date:  2021-07-28       Impact factor: 3.540

Review 7.  The mechanisms of action of metformin.

Authors:  Graham Rena; D Grahame Hardie; Ewan R Pearson
Journal:  Diabetologia       Date:  2017-08-03       Impact factor: 10.122

8.  New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform.

Authors:  Rokon Uddin; Graham Rena; En-Te Hwu; Anja Boisen
Journal:  ACS Sens       Date:  2017-08-18       Impact factor: 7.711
  8 in total

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