Literature DB >> 26462764

U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA.

Richard G Wong1, Katelynn Kazane2, Dmitri A Maslov3, Kestrel Rogers4, Ruslan Aphasizhev5, Larry Simpson6.   

Abstract

We studied the intramitochondrial localization of several multiprotein complexes involved in U-insertion/deletion RNA editing in trypanosome mitochondria. The editing complexes are located in one or two antipodal nodes adjacent to the kinetoplast DNA (kDNA) disk, which are distinct from but associated with the minicircle catenation nodes. In some cases the proteins are in a bilateral sheet configuration. We also found that mitoribosomes have a nodal configuration. This type of organization is consistent with evidence for protein and RNA interactions of multiple editing complexes to form an ~40S editosome and also an interaction of editosomes with mitochondrial ribosomes.
Copyright © 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Entities:  

Keywords:  Antipodal node; Editing; Kinetoplast; Leishmania; RNA; Trypanosome

Mesh：

Substances：

Year:  2015        PMID： 26462764      PMCID： PMC4671395          DOI： 10.1016/j.mito.2015.10.006

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


  60 in total

1.  A high-order trans-membrane structural linkage is responsible for mitochondrial genome positioning and segregation by flagellar basal bodies in trypanosomes.

Authors:  Emmanuel O Ogbadoyi; Derrick R Robinson; Keith Gull
Journal:  Mol Biol Cell       Date:  2003-03-07       Impact factor: 4.138

2.  The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing.

Authors:  D A Maslov; L Simpson
Journal:  Cell       Date:  1992-08-07       Impact factor: 41.582

3.  RNA binding and core complexes constitute the U-insertion/deletion editosome.

Authors:  Inna Aphasizheva; Liye Zhang; Xiaorong Wang; Robyn M Kaake; Lan Huang; Stefano Monti; Ruslan Aphasizhev
Journal:  Mol Cell Biol       Date:  2014-09-15       Impact factor: 4.272

4.  Reconstitution of full-round uridine-deletion RNA editing with three recombinant proteins.

Authors:  Xuedong Kang; Guanghan Gao; Kestrel Rogers; Arnold M Falick; Sharleen Zhou; Larry Simpson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-08       Impact factor: 11.205

5.  Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae.

Authors:  Susanna Kushnir; Ion Cristian Cirstea; Lyudmyla Basiliya; Nataliya Lupilova; Reinhard Breitling; Kirill Alexandrov
Journal:  Mol Biochem Parasitol       Date:  2010-12-15       Impact factor: 1.759

6.  TbPIF8, a Trypanosoma brucei protein related to the yeast Pif1 helicase, is essential for cell viability and mitochondrial genome maintenance.

Authors:  Jianyang Wang; Paul T Englund; Robert E Jensen
Journal:  Mol Microbiol       Date:  2012-01-04       Impact factor: 3.501

7.  Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes.

Authors:  Tina T Saxowsky; Gunjan Choudhary; Michele M Klingbeil; Paul T Englund
Journal:  J Biol Chem       Date:  2003-09-08       Impact factor: 5.157

8.  Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance.

Authors:  Felix Schnarwiler; Moritz Niemann; Nicholas Doiron; Anke Harsman; Sandro Käser; Jan Mani; Astrid Chanfon; Caroline E Dewar; Silke Oeljeklaus; Christopher B Jackson; Mascha Pusnik; Oliver Schmidt; Chris Meisinger; Sebastian Hiller; Bettina Warscheid; Achim C Schnaufer; Torsten Ochsenreiter; André Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-12       Impact factor: 11.205

9.  A Trypanosoma brucei protein required for maintenance of the flagellum attachment zone and flagellar pocket ER domains.

Authors:  Sylvain Lacomble; Sue Vaughan; Michaël Deghelt; Flávia Fernandes Moreira-Leite; Keith Gull
Journal:  Protist       Date:  2011-12-18

10.  Secretory signal peptide modification for optimized antibody-fragment expression-secretion in Leishmania tarentolae.

Authors:  Stephan Klatt; Zoltán Konthur
Journal:  Microb Cell Fact       Date:  2012-07-25       Impact factor: 5.328
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  3 in total

1.  The Mitochondrial Cytochrome Oxidase Subunit I Gene Occurs on a Minichromosome with Extensive Heteroplasmy in Two Species of Chewing Lice, Geomydoecus aurei and Thomomydoecus minor.

Authors:  Lucas L Pietan; Theresa A Spradling; James W Demastes
Journal:  PLoS One       Date:  2016-09-02       Impact factor: 3.240

Review 2.  Leishmania tarentolae: Taxonomic classification and its application as a promising biotechnological expression host.

Authors:  Stephan Klatt; Larry Simpson; Dmitri A Maslov; Zoltán Konthur
Journal:  PLoS Negl Trop Dis       Date:  2019-07-25

Review 3.  Separating the Wheat from the Chaff: RNA Editing and Selection of Translatable mRNA in Trypanosome Mitochondria.

Authors:  Dmitri A Maslov
Journal:  Pathogens       Date:  2019-07-18
  3 in total

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