Literature DB >> 26462756

Hippocampal insulin resistance and cognitive dysfunction.

Geert Jan Biessels1, Lawrence P Reagan2,3.   

Abstract

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.

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Year:  2015        PMID： 26462756     DOI： 10.1038/nrn4019

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  168 in total

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Journal:  FASEB J       Date:  2007-08-24       Impact factor: 5.191

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Authors:  C E Greenwood; G Winocur
Journal:  Behav Neurosci       Date:  1996-06       Impact factor: 1.912

Review 4.  A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes.

Authors:  Walid K H Fakhoury; Corinne Lereun; Donna Wright
Journal:  Pharmacology       Date:  2010-07-12       Impact factor: 2.547

Review 5.  Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future.

Authors:  Steven E Kahn; Mark E Cooper; Stefano Del Prato
Journal:  Lancet       Date:  2013-12-03       Impact factor: 79.321

6.  Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice.

Authors:  Alexis M Stranahan; Kim Lee; Bronwen Martin; Stuart Maudsley; Erin Golden; Roy G Cutler; Mark P Mattson
Journal:  Hippocampus       Date:  2009-10       Impact factor: 3.899

7.  DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats.

Authors:  Hiranya Pintana; Nattayaporn Apaijai; Nipon Chattipakorn; Siriporn C Chattipakorn
Journal:  J Endocrinol       Date:  2013-05-28       Impact factor: 4.286

8.  Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging.

Authors:  Madhav Thambisetty; E Jeffrey Metter; An Yang; Hillary Dolan; Christopher Marano; Alan B Zonderman; Juan C Troncoso; Yun Zhou; Dean F Wong; Luigi Ferrucci; Josephine Egan; Susan M Resnick; Richard J O'Brien
Journal:  JAMA Neurol       Date:  2013-09-01       Impact factor: 18.302

Review 9.  The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling.

Authors:  Suneng Fu; Steven M Watkins; Gökhan S Hotamisligil
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

10.  Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus.

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Journal:  Neuroendocrinology       Date:  2007-04-05       Impact factor: 4.914
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  144 in total

1.  Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer's Disease.

Authors:  Miren Ettcheto; Elena Sánchez-López; Yaiza Gómez-Mínguez; Henrry Cabrera; Oriol Busquets; Carlos Beas-Zarate; Maria Luisa García; Eva Carro; Gemma Casadesus; Carme Auladell; Manuel Vázquez Carrera; Jaume Folch; Antoni Camins
Journal:  Mol Neurobiol       Date:  2018-02-05       Impact factor: 5.590

2.  Time-course study of high fat diet induced alterations in spatial memory, hippocampal JNK, P38, ERK and Akt activity.

Authors:  Zahra Abbasnejad; Behzad Nasseri; Homeira Zardooz; Rasoul Ghasemi
Journal:  Metab Brain Dis       Date:  2018-12-14       Impact factor: 3.584

3.  Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer's disease.

Authors:  Junling Yang; Jinghong Kou; Robert Lalonde; Ken-Ichiro Fukuchi
Journal:  Brain Behav Immun       Date:  2017-05-17       Impact factor: 7.217

Review 4.  Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications.

Authors:  Geert Jan Biessels; Florin Despa
Journal:  Nat Rev Endocrinol       Date:  2018-10       Impact factor: 43.330

5.  Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance.

Authors:  Masaki Yamamoto; De-Huang Guo; Caterina M Hernandez; Alexis M Stranahan
Journal:  J Neurosci       Date:  2019-03-18       Impact factor: 6.167

6.  Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats.

Authors:  Joao Tomé-Carneiro; M Carmen Crespo; Emma Burgos-Ramos; Cristina Tomas-Zapico; Alba García-Serrano; Pilar Castro-Gómez; Cesar Venero; Inmaculada Pereda-Pérez; Shishir Baliyan; Azucena Valencia; Javier Fontecha; Alberto Dávalos; Francesco Visioli
Journal:  Mol Neurobiol       Date:  2018-02-03       Impact factor: 5.590

7.  Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring.

Authors:  Zachary A Cordner; Seva G Khambadkone; Gretha J Boersma; Lin Song; Tyler N Summers; Timothy H Moran; Kellie L K Tamashiro
Journal:  Exp Neurol       Date:  2019-04-30       Impact factor: 5.330

Review 8.  The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein: Its Role and Function in Extrapulmonary Disease.

Authors:  Theodore G Liou
Journal:  Chest       Date:  2018-10-22       Impact factor: 9.410

9.  Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits.

Authors:  Jim R Fadel; Lawrence P Reagan
Journal:  Curr Opin Behav Sci       Date:  2015-12-01

10.  Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats.

Authors:  Gemma Sangüesa; Mar Cascales; Christian Griñán; Rosa María Sánchez; Núria Roglans; Mercè Pallàs; Juan Carlos Laguna; Marta Alegret
Journal:  Mol Neurobiol       Date:  2018-01-26       Impact factor: 5.590
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