Abdulla Watad1,2, Arnon D Cohen3,4, Doron Comaneshter3, Dorit Tekes-Manova5, Howard Amital1,2. 1. a Department of Medicine 'B' , Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center , Tel-Hashomer , Israel . 2. b Sackler Faculty of Medicine , Tel-Aviv University , Tel-Aviv , Israel . 3. c Chief Physician's Office, Clalit Health Services , Tel Aviv , Israel . 4. d Faculty of Health Sciences , Siaal Research Center for Family Medicine and Primary Care, Ben Gurion University of the Negev , Beer Sheva , Israel , and. 5. e Chaim Sheba General Hospital, Sheba Medical Center , Tel-Hashomer , Israel.
Abstract
BACKGROUND: Despite the frequently encountered association between thyroid disease and systemic lupus erythematosus (SLE) is well known, it is of surprise that only several reports compromised of small population size support this observation. OBJECTIVES: To investigate the association of comorbid SLE and hyperthyroidism. METHODS: Using the database of the largest health maintenance organization (HMO) in Israel, the Clalit Health Services, we searched for the co-existence of SLE and hyperthyroidism. Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of hyperthyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. RESULTS: The study included 5018 patients with SLE and 25,090 age- and sex- matched controls. The prevalence of hyperthyroidism in patients with SLE was increased compared with the prevalence in controls (2.59% and 0.91%, respectively, p < 0.001). In a multivariate analysis, SLE was associated with hyperthyroidism (odds ratio 2.52, 95% confidence interval 2.028-3.137). CONCLUSIONS: Patients with SLE have a greater prevalence of hyperthyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of this possibility of this thyroid dysfunction.
BACKGROUND: Despite the frequently encountered association between thyroid disease and systemic lupus erythematosus (SLE) is well known, it is of surprise that only several reports compromised of small population size support this observation. OBJECTIVES: To investigate the association of comorbid SLE and hyperthyroidism. METHODS: Using the database of the largest health maintenance organization (HMO) in Israel, the Clalit Health Services, we searched for the co-existence of SLE and hyperthyroidism. Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of hyperthyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. RESULTS: The study included 5018 patients with SLE and 25,090 age- and sex- matched controls. The prevalence of hyperthyroidism in patients with SLE was increased compared with the prevalence in controls (2.59% and 0.91%, respectively, p < 0.001). In a multivariate analysis, SLE was associated with hyperthyroidism (odds ratio 2.52, 95% confidence interval 2.028-3.137). CONCLUSIONS:Patients with SLE have a greater prevalence of hyperthyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of this possibility of this thyroid dysfunction.
Authors: Abdulla Watad; Arsalan Abu Much; Danielle Bracco; Naim Mahroum; Doron Comaneshter; Arnon D Cohen; Howard Amital Journal: Immunol Res Date: 2017-04 Impact factor: 2.829
Authors: Tal Gonen; Shmuel Tiosano; Doron Comaneshter; Howard Amital; Arnon D Cohen; Ora Shovman Journal: Rheumatol Int Date: 2019-10-19 Impact factor: 2.631
Authors: S Tiosano; A Farhi; A Watad; N Grysman; R Stryjer; H Amital; D Comaneshter; A D Cohen; D Amital Journal: Epidemiol Psychiatr Sci Date: 2016-07-26 Impact factor: 6.892