| Literature DB >> 26462463 |
Paula Miro1, Virginie Lhiaubet-Vallet1, M Luisa Marin2, Miguel A Miranda3.
Abstract
A new mechanism of photosensitized formation of thymine (Thy) dimers is proposed, which involves generation of a delocalized triplet excited state as the key step. This is supported by chemical evidence obtained by combining one benzophenone and two Thy units with different degrees of freedom, whereby the photoreactivity is switched from a clean Paternò-Büchi reaction to a fully chemo-, regio-, and stereoselective [2+2] cycloaddition.Entities:
Keywords: DNA damage; dimerization; nucleobases; photochemistry; reaction mechanisms
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Year: 2015 PMID： 26462463 DOI： 10.1002/chem.201502719
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236