BACKGROUND: Mass drug administration (MDA) with azithromycin is an important part of trachoma control programs. Maintaining high participation among children is challenging. AIM: We assessed factors identifying households with a child who changed participation from the first MDA to the second MDA compared to households where all children participated at both MDAs. METHODS: Two case-control comparisons were conducted in 11 Tanzanian communities, which underwent MDA in 2008 and 2009. The first case group (n=165) was a random sample of households with a child who changed from a 2008 non-participant to a 2009 participant (delayed participant). The second case group (n=165) was a random sample of households with a child who went from a 2008 participant to a 2009 non-participant (change to non-participant). Controls (n=330) were a random sample of households where all children participated in both rounds. Risk factors were assessed using questionnaires asked of children's guardians. Logistic models with a random-intercept were used to estimate odds ratios and 95% confidence intervals. RESULTS: Households with delayed participation were more likely to be in communities with fewer treatment days (OR=2.98, 95% CI=1.80-4.92) and assigned to Community Treatment Assistants (CTA) with a wide area to cover (OR=1.88, 95% CI=1.09-3.23). Households with change to non-participation were more likely to live further from the distribution site (OR=3.17, 95% CI=1.19-8.46), have the guardian born outside the village with short-term residency (OR=2.64, 95% CI=1.32-5.31), and be assigned to a male CTA (OR=1.75, 95% CI=1.08-2.83). CONCLUSIONS: Factors related to program accessibility were associated with delayed participation and maintaining participation.
BACKGROUND: Mass drug administration (MDA) with azithromycin is an important part of trachoma control programs. Maintaining high participation among children is challenging. AIM: We assessed factors identifying households with a child who changed participation from the first MDA to the second MDA compared to households where all children participated at both MDAs. METHODS: Two case-control comparisons were conducted in 11 Tanzanian communities, which underwent MDA in 2008 and 2009. The first case group (n=165) was a random sample of households with a child who changed from a 2008 non-participant to a 2009 participant (delayed participant). The second case group (n=165) was a random sample of households with a child who went from a 2008 participant to a 2009 non-participant (change to non-participant). Controls (n=330) were a random sample of households where all children participated in both rounds. Risk factors were assessed using questionnaires asked of children's guardians. Logistic models with a random-intercept were used to estimate odds ratios and 95% confidence intervals. RESULTS: Households with delayed participation were more likely to be in communities with fewer treatment days (OR=2.98, 95% CI=1.80-4.92) and assigned to Community Treatment Assistants (CTA) with a wide area to cover (OR=1.88, 95% CI=1.09-3.23). Households with change to non-participation were more likely to live further from the distribution site (OR=3.17, 95% CI=1.19-8.46), have the guardian born outside the village with short-term residency (OR=2.64, 95% CI=1.32-5.31), and be assigned to a male CTA (OR=1.75, 95% CI=1.08-2.83). CONCLUSIONS: Factors related to program accessibility were associated with delayed participation and maintaining participation.
Entities:
Keywords:
Trachoma; azithromycin; mass drug administration
Authors: Dianne Stare; Emma Harding-Esch; Beatriz Munoz; Robin Bailey; David Mabey; Martin Holland; Charlotte Gaydos; Sheila West Journal: Ophthalmic Epidemiol Date: 2011-02 Impact factor: 1.648
Authors: Evertjan Jansen; Rob M P M Baltussen; Eddy van Doorslaer; Edith Ngirwamungu; Mai P Nguyen; Peter M Kilima Journal: Ophthalmic Epidemiol Date: 2007 Sep-Oct Impact factor: 1.648
Authors: Veronica L Tallo; Hélène Carabin; Portia P Alday; Ernesto Balolong; Remigio M Olveda; Stephen T McGarvey Journal: Bull World Health Organ Date: 2008-10 Impact factor: 9.408
Authors: Isobel M Blake; Matthew J Burton; Robin L Bailey; Anthony W Solomon; Sheila West; Beatriz Muñoz; Martin J Holland; David C W Mabey; Manoj Gambhir; María-Gloria Basáñez; Nicholas C Grassly Journal: PLoS Negl Trop Dis Date: 2009-03-31
Authors: Caleb D Ebert; Tigist Astale; Eshetu Sata; Mulat Zerihun; Andrew W Nute; Aisha E P Stewart; Demelash Gessese; Gedefaw Ayenew; Zebene Ayele; Berhanu Melak; Melsew Chanyalew; Bizuayehu Gashaw; Zerihun Tadesse; E Kelly Callahan; Samuel M Jenness; Scott D Nash Journal: Trop Med Int Health Date: 2019-02-10 Impact factor: 2.622
Authors: Tansy Edwards; Elizabeth Allen; Emma M Harding-Esch; John Hart; Sarah E Burr; Martin J Holland; Ansumana Sillah; Sheila K West; David Mabey; Robin Bailey Journal: PLoS Negl Trop Dis Date: 2014-08-28