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Literature DB >> 2646222

6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis.

Abstract

The role of immunosuppressives in the treatment of Crohn's disease and ulcerative colitis will be reviewed. This will include a comprehensive presentation of the uncontrolled and controlled studies in both diseases. The author's personal experiences with more than 400 patients will be summarized, including efficacy and short- and long-term toxicity. A review of the literature regarding the risk of superinfections and neoplasia will be presented. Finally, specific indications for the use of 6-MP/azathioprine will be listed.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2646222

Source DB: PubMed Journal: Gastroenterol Clin North Am ISSN： 0889-8553 Impact factor: 3.806

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Cited

14 in total

Review 1. Drug therapy of ulcerative colitis.

Authors: B Crotty; D P Jewell
Journal: Br J Clin Pharmacol Date: 1992-09 Impact factor: 4.335

2. Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis.

Authors: L Braslow
Journal: Ann Surg Date: 1991-04 Impact factor: 12.969

3. Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis.

Authors: Satheesh K Sainathan; Kumar S Bishnupuri; Konrad Aden; Qizhi Luo; Courtney W Houchen; Shrikant Anant; Brian K Dieckgraefe
Journal: Inflamm Bowel Dis Date: 2011-09-26 Impact factor: 5.325

Review 4. Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment.

Authors: E G Quetglas; A Armuzzi; S Wigge; G Fiorino; L Barnscheid; M Froelich; Silvio Danese
Journal: Eur J Clin Pharmacol Date: 2015-05-27 Impact factor: 2.953

5. Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon.

Authors: S N Murthy; T Anania; H R Clearfield
Journal: Agents Actions Date: 1991-09

6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis.

Review 1. Drug therapy of ulcerative colitis.

2. Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis.

3. Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis.

Review 4. Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment.

5. Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon.

Review 6. Inflammatory bowel disease in the elderly. Practical treatment guidelines.

Review 7. Monitoring thiopurine metabolites in inflammatory bowel disease.

8. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin.

9. Low-dose 6-mercaptopurine in inflammatory bowel disease is associated with minimal hematologic toxicity.

Review 10. New developments in the pharmacotherapy of inflammatory bowel disease.