Literature DB >> 26461174

An Organocatalytic Biomimetic Strategy Paves the Way for the Asymmetric Umpolung of Imines.

Mario Waser1, Johanna Novacek2.   

Abstract

Just like Nature: A recently developed enantioselective organocatalytic biomimetic transamination provides an elegant approach towards chiral amines. In the presence of an asymmetric phase-transfer catalyst, the intermediate anionic species undergoes an asymmetric C-C bond-forming reaction in a powerful and broadly applicable asymmetric umpolung strategy.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  asymmetric catalysis; organocatalysis; phase-transfer catalysis; transamination; umpolung

Year:  2015        PMID： 26461174     DOI： 10.1002/anie.201506872

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  5 in total

1.  Proton-Coupled Reduction of an Iron Cyanide Complex to Methane and Ammonia.

Authors:  Jonathan Rittle; Jonas C Peters
Journal:  Angew Chem Int Ed Engl       Date:  2016-09-08       Impact factor: 15.336

2.  Control of chemoselectivity in asymmetric tandem reactions: Direct synthesis of chiral amines bearing nonadjacent stereocenters.

Authors:  Zhe Li; Bin Hu; Yongwei Wu; Chao Fei; Li Deng
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-05       Impact factor: 11.205

3.  Catalytic Asymmetric Synthesis of Trifluoromethylated γ-Amino Acids through the Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives.

Authors:  Bin Hu; Li Deng
Journal:  Angew Chem Int Ed Engl       Date:  2018-01-18       Impact factor: 15.336

4.  Synthesis of α-CF3-proline derivatives by means of a formal (3 + 2)-cyclisation between trifluoropyruvate imines and Michael acceptors.

Authors:  Michael Winter; Kirill Faust; Markus Himmelsbach; Mario Waser
Journal:  Org Biomol Chem       Date:  2019-06-12       Impact factor: 3.876

5.  Pd-Catalyzed Allylation of Imines to Access α-CF3-Substituted α-Amino Acid Derivatives.

Authors:  Michael Winter; Hyunwoo Kim; Mario Waser
Journal:  European J Org Chem       Date:  2019-10-09
  5 in total

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