| Literature DB >> 26461084 |
Daniel R Holohan1, James C Lee1, Jeffrey A Bluestone2.
Abstract
In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.Entities:
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Year: 2015 PMID： 26461084 DOI： 10.1016/j.ccell.2015.09.014
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743