| Literature DB >> 26460883 |
Pramod K Sahu1, Tamima Umme2, Jinha Yu1, Akshata Nayak1,2, Gyudong Kim1, Minsoo Noh1, Jae-Young Lee1, Dae-Duk Kim1, Lak Shin Jeong1.
Abstract
On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.Entities:
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Year: 2015 PMID： 26460883 DOI： 10.1021/acs.jmedchem.5b00804
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446