M R M San Giorgi1,2, E R van den Heuvel3, R E A Tjon Pian Gi1,2, J W Brunings4, M Chirila5, G Friedrich6, W Golusinski7, M Graupp6, R A Horcasitas Pous8, T Ilmarinen9, J Jackowska10, J C Koelmel11, F Ferran Vilà12, V Weichbold13, M Wierzbicka10, F G Dikkers14,15. 1. Department of Otorhinolaryngology/Head & Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 2. Cancer Research Center Groningen, University of Groningen, Groningen, The Netherlands. 3. Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands. 4. Department of Otorhinolaryngology/Head & Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands. 5. Department of Otorhinolaryngology/Head & Neck Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. 6. Department of Phoniatrics, Speech and Swallowing, Ear, Nose and Throat University Hospital, Medical University of Graz, Graz, Austria. 7. Department of Otorhinolaryngology, Greater Poland Cancer Centre, Poznań, Poland. 8. Pediatric Otolaryngology, Hospital Infantil del Estado de Chihuahua, Chihuahua, Mexico. 9. Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. 10. Department of Otolaryngology - Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland. 11. Klinik für Hals-, Nasen-, Ohrenkrankheiten, Plastische Operationen, Klinikum-Stuttgart, Stuttgart, Germany. 12. Consulta d'ORL, foniatria i logopèdia, Hosp. Gral de Catalunya (Sant Cugat del Vallès), Barcelona, Spain. 13. Department for Hearing Speech and Voice Disorders, Medical University Innsbruck, Innsbruck, Austria. 14. Department of Otorhinolaryngology/Head & Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. f.g.dikkers@umcg.nl. 15. Cancer Research Center Groningen, University of Groningen, Groningen, The Netherlands. f.g.dikkers@umcg.nl.
Abstract
OBJECTIVE: Distribution of age of onset of recurrent respiratory papillomatosis (RRP) is generally described to be bimodal, with peaks at approximately 5 years and 30 years. This assumption has never been scientifically confirmed, and authors tend to refer to an article that does not describe distribution. Knowledge of the distribution of age of onset is important for virological and epidemiological comprehension. The objective of this study was to determine the distribution of age of onset of RRP in a large international sample. DESIGN: Cross-sectional distribution analysis. PARTICIPANTS: Laryngologists from 12 European hospitals provided information on date of birth and date of onset of all their RRP patients treated between 1998 and 2012. Centers that exclusively treated either patients with juvenile onset RRP or patients with adult onset RRP, or were less accessible for one of these groups, were excluded to prevent skewness. MAIN OUTCOME MEASURES: A mixture model was implemented to describe distribution of age of onset. The best fitting model was selected using the Bayesian information criterion. RESULTS: Six hundred and thirty-nine patients were included in the analysis. Age of onset was described by a three component mixture distribution with lognormally distributed components. Recurrent respiratory papillomatosis starts at three median ages 7, 35 and 64 years. CONCLUSIONS: Distribution of age of onset of RRP shows three peaks. In addition to the already adopted idea of age peaks at paediatric and adult age, there is an additional peak around the age of 64.
OBJECTIVE: Distribution of age of onset of recurrent respiratory papillomatosis (RRP) is generally described to be bimodal, with peaks at approximately 5 years and 30 years. This assumption has never been scientifically confirmed, and authors tend to refer to an article that does not describe distribution. Knowledge of the distribution of age of onset is important for virological and epidemiological comprehension. The objective of this study was to determine the distribution of age of onset of RRP in a large international sample. DESIGN: Cross-sectional distribution analysis. PARTICIPANTS: Laryngologists from 12 European hospitals provided information on date of birth and date of onset of all their RRP patients treated between 1998 and 2012. Centers that exclusively treated either patients with juvenile onset RRP or patients with adult onset RRP, or were less accessible for one of these groups, were excluded to prevent skewness. MAIN OUTCOME MEASURES: A mixture model was implemented to describe distribution of age of onset. The best fitting model was selected using the Bayesian information criterion. RESULTS: Six hundred and thirty-nine patients were included in the analysis. Age of onset was described by a three component mixture distribution with lognormally distributed components. Recurrent respiratory papillomatosis starts at three median ages 7, 35 and 64 years. CONCLUSIONS: Distribution of age of onset of RRP shows three peaks. In addition to the already adopted idea of age peaks at paediatric and adult age, there is an additional peak around the age of 64.
Authors: F Scasso; G Ferrari; G C DE Vincentiis; A Arosio; S Bottero; M Carretti; A Ciardo; S Cocuzza; A Colombo; B Conti; A Cordone; M DE Ciccio; E Delehaye; L Della Vecchia; I DE Macina; C Dentone; P DI Mauro; R Dorati; R Fazio; A Ferrari; G Ferrea; S Giannantonio; I Genta; M Giuliani; D Lucidi; L Maiolino; G Marini; P Marsella; D Meucci; T Modena; B Montemurri; A Odone; S Palma; M L Panatta; M Piemonte; P Pisani; S Pisani; L Prioglio; A Scorpecci; L Scotto DI Santillo; A Serra; C Signorelli; E Sitzia; M L Tropiano; M Trozzi; F M Tucci; L Vezzosi; B Viaggi Journal: Acta Otorhinolaryngol Ital Date: 2018-04 Impact factor: 2.124
Authors: Farrel J Buchinsky; William L Valentino; Nicole Ruszkay; Evan Powell; Craig S Derkay; Riaz Y Seedat; Virgilijus Uloza; Frederik G Dikkers; David E Tunkel; Sukgi S Choi; Anthony J Mortelliti; Paolo Campisi; Juan C Ospina; Adam J Donne; Robert T Sataloff; Stephen F Conley; John E McClay; Ellen M Friedman; Lisa Elden; Dale A Tylor; Clark A Rosen; Libby J Smith; Graeme J Copley; David E Karas; John M Schweinfurth; Charles M Myer; Brian J Wiatrak; Joseph E Dohar; Steven E Sobol; Robert W Bastian; Richard J H Smith; Marshall E Smith; Abebe M Wassie; James C Post; Garth D Ehrlich Journal: PLoS One Date: 2019-06-13 Impact factor: 3.240