Literature DB >> 26460143

Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.

Atsuko Ikeda1, Kentaro Kajiwara1, Kunihiko Iwamoto2, Asami Makino2, Toshihide Kobayashi2, Keiko Mizuta1, Kouichi Funato1.   

Abstract

ARV1 is involved in regulating lipid homeostasis but also in the biosynthesis of glycosylphosphatidylinositol (GPI) in Saccharomyces cerevisiae. Here, we examined whether human ARV1 can complement the role of yeast ARV1 in GPI biosynthesis. Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Δ mutant. The results suggest that Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans.
Copyright © 2015 John Wiley & Sons, Ltd.

Entities:  

Keywords:  GPI anchor; arv1Δ mutant; complementation; human ARV1; yeast

Mesh：

Substances：

Year:  2015        PMID： 26460143     DOI： 10.1002/yea.3138

Source DB:  PubMed          Journal:  Yeast        ISSN： 0749-503X            Impact factor:   3.239


  7 in total

1.  Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.

Authors:  Elizabeth E Palmer; Kelsey E Jarrett; Rani K Sachdev; Fatema Al Zahrani; Mais Omar Hashem; Niema Ibrahim; Hugo Sampaio; Tejaswi Kandula; Rebecca Macintosh; Rajat Gupta; Donna M Conlon; Jeffrey T Billheimer; Daniel J Rader; Kouichi Funato; Christopher J Walkey; Chang Seok Lee; Christine Loo; Susan Brammah; George Elakis; Ying Zhu; Michael Buckley; Edwin P Kirk; Ann Bye; Fowzan S Alkuraya; Tony Roscioli; William R Lagor
Journal:  Hum Mol Genet       Date:  2016-06-06       Impact factor: 6.150

2.  A lipid regulator working at the cleavage furrow.

Authors:  Katsuki Eto; Hiroto Denda; Kouichi Funato
Journal:  Cell Cycle       Date:  2016-04-22       Impact factor: 4.534

3.  Homozygous splice-variants in human ARV1 cause GPI-anchor synthesis deficiency.

Authors:  Mariska Davids; Minal Menezes; Yiran Guo; Scott D McLean; Hakon Hakonarson; Felicity Collins; Lisa Worgan; Charles J Billington; Irina Maric; Rebecca Okashah Littlejohn; Tito Onyekweli; David R Adams; Cynthia J Tifft; William A Gahl; Lynne A Wolfe; John Christodoulou; May Christine V Malicdan
Journal:  Mol Genet Metab       Date:  2020-02-10       Impact factor: 4.797

4.  Ras signaling activates glycosylphosphatidylinositol (GPI) anchor biosynthesis via the GPI-N-acetylglucosaminyltransferase (GPI-GnT) in Candida albicans.

Authors:  Priyanka Jain; Subhash Chandra Sethi; Vavilala A Pratyusha; Pramita Garai; Nilofer Naqvi; Sonali Singh; Kalpana Pawar; Niti Puri; Sneha Sudha Komath
Journal:  J Biol Chem       Date:  2018-06-15       Impact factor: 5.157

5.  Migrating Focal Seizures and Myoclonic Status in ARV1-Related Encephalopathy.

Authors:  Francesca Darra; Tommaso Lo Barco; Roberta Opri; Elena Parrini; Claudia Bianchini; Elena Fiorini; Alessandro Simonati; Bernardo Dalla Bernardina; Gaetano Cantalupo; Renzo Guerrini
Journal:  Neurol Genet       Date:  2021-05-14

6.  Proteomic identification of the UDP-GlcNAc: PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.

Authors:  Zhe Ji; Michele Tinti; Michael A J Ferguson
Journal:  PLoS One       Date:  2021-03-18       Impact factor: 3.240

Review 7.  Biosynthesis and biology of mammalian GPI-anchored proteins.

Authors:  Taroh Kinoshita
Journal:  Open Biol       Date:  2020-03-11       Impact factor: 6.411
  7 in total

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