Literature DB >> 26459891

A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii.

Chui-Yoke Chin1, Kelsey A Gregg2, Brooke A Napier3, Robert K Ernst2, David S Weiss4.   

Abstract

Emerging resistance to "last-resort" polymyxin antibiotics in Gram-negative bacteria is a significant threat to public health. We identified the Acinetobacter baumannii NaxD deacetylase as a critical mediator of lipid A modification resulting in polymyxin resistance and demonstrated that naxD is regulated by the sensor kinase PmrB. This represents the first description of a specific PmrB-regulated gene contributing to polymyxin resistance in A. baumannii and highlights NaxD as a putative drug target to reverse polymyxin resistance.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26459891      PMCID： PMC4649237          DOI： 10.1128/AAC.00515-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

Review 1.  The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more.

Authors:  John S Gunn
Journal:  Trends Microbiol       Date:  2008-05-06       Impact factor: 17.079

2.  Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar typhimurium.

Authors:  A Aguirre; S Lejona; E G Véscovi; F C Soncini
Journal:  J Bacteriol       Date:  2000-07       Impact factor: 3.490

3.  The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A.

Authors:  Luis A Arroyo; Carmen M Herrera; Lucia Fernandez; Jessica V Hankins; M Stephen Trent; Robert E W Hancock
Journal:  Antimicrob Agents Chemother       Date:  2011-06-06       Impact factor: 5.191

Review 4.  Polymyxins and their novel derivatives.

Authors:  Martti Vaara
Journal:  Curr Opin Microbiol       Date:  2010-09-24       Impact factor: 7.934

5.  Identification and genetic characterization of PmrA-regulated genes and genes involved in polymyxin B resistance in Salmonella enterica serovar typhimurium.

Authors:  Rita Tamayo; Sara S Ryan; Andrea J McCoy; John S Gunn
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

6.  Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin.

Authors:  I K Neonakis; G Samonis; H Messaritakis; S Baritaki; A Georgiladakis; S Maraki; D A Spandidos
Journal:  Chemotherapy       Date:  2010-11-18       Impact factor: 2.544

7.  Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.

Authors:  Joseph B McPhee; Shawn Lewenza; Robert E W Hancock
Journal:  Mol Microbiol       Date:  2003-10       Impact factor: 3.501

8.  Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii.

Authors:  Mark R Pelletier; Leila G Casella; Jace W Jones; Mark D Adams; Daniel V Zurawski; Karsten R O Hazlett; Yohei Doi; Robert K Ernst
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

9.  Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system.

Authors:  Mark D Adams; Gabrielle C Nickel; Saralee Bajaksouzian; Heather Lavender; A Rekha Murthy; Michael R Jacobs; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191

10.  In silico identification and experimental validation of PmrAB targets in Salmonella typhimurium by regulatory motif detection.

Authors:  Kathleen Marchal; Sigrid De Keersmaecker; Pieter Monsieurs; Nadja van Boxel; Karen Lemmens; Gert Thijs; Jos Vanderleyden; Bart De Moor
Journal:  Genome Biol       Date:  2004-01-29       Impact factor: 13.583
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  20 in total

Review 1.  Pathogenic Acinetobacter: from the Cell Surface to Infinity and Beyond.

Authors:  Brent S Weber; Christian M Harding; Mario F Feldman
Journal:  J Bacteriol       Date:  2015-12-28       Impact factor: 3.490

Review 2.  Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB.

Authors:  Jiayuan Huang; Chen Li; Jiangning Song; Tony Velkov; Lushan Wang; Yan Zhu; Jian Li
Journal:  Future Microbiol       Date:  2020-04-06       Impact factor: 3.165

Review 3.  Multidrug Resistant Acinetobacter baumannii: Resistance by Any Other Name Would Still be Hard to Treat.

Authors:  David A Butler; Mark Biagi; Xing Tan; Samah Qasmieh; Zackery P Bulman; Eric Wenzler
Journal:  Curr Infect Dis Rep       Date:  2019-11-16       Impact factor: 3.725

Review 4.  Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Authors:  Sue C Nang; Mohammad A K Azad; Tony Velkov; Qi Tony Zhou; Jian Li
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468

Review 5.  Expanding the paradigm for the outer membrane: Acinetobacter baumannii in the absence of endotoxin.

Authors:  Matthew Joseph Powers; M Stephen Trent
Journal:  Mol Microbiol       Date:  2017-11-20       Impact factor: 3.501

6.  Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance.

Authors:  Soon-Ee Cheah; Jian Li; Brian T Tsuji; Alan Forrest; Jürgen B Bulitta; Roger L Nation
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

Review 7.  Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy.

Authors:  Bora Shin; Woojun Park
Journal:  J Microbiol       Date:  2017-10-27       Impact factor: 3.422

Review 8.  Uncovering the mechanisms of Acinetobacter baumannii virulence.

Authors:  Christian M Harding; Seth W Hennon; Mario F Feldman
Journal:  Nat Rev Microbiol       Date:  2017-12-18       Impact factor: 60.633

9.  Emergence of High-Level Colistin Resistance in an Acinetobacter baumannii Clinical Isolate Mediated by Inactivation of the Global Regulator H-NS.

Authors:  Deanna Deveson Lucas; Bethany Crane; Amy Wright; Mei-Ling Han; Jennifer Moffatt; Dieter Bulach; Simon L Gladman; David Powell; Jesus Aranda; Torsten Seemann; Diana Machado; Teresa Pacheco; Teresa Marques; Miguel Viveiros; Roger Nation; Jian Li; Marina Harper; John D Boyce
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

10.  Antimicrobial Resistance Mechanisms and Virulence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii Isolated from a Teaching Hospital in Taiwan.

Authors:  Noor Andryan Ilsan; Yuarn-Jang Lee; Shu-Chen Kuo; I-Hui Lee; Tzu-Wen Huang
Journal:  Microorganisms       Date:  2021-06-14
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