Literature DB >> 2645864

Stimulation of insulin secretion by transforming growth factor-beta.

Y Totsuka1, M Tabuchi, I Kojima, Y Eto, H Shibai, E Ogata.   

Abstract

Effects of transforming growth factor-beta (TGF-beta) on insulin secretion were studied in rat pancreatic islets. When islets were incubated in a batch incubation system with various concentrations of TGF-beta in the presence of 2.8 mM glucose, TGF- beta increased insulin release in a concentration-dependent manner. Both TGF- beta 1 and TGF- beta 2 were equally effective. The stimulatory action of TGF- beta was greater in the presence of stimulatory concentration of glucose. In perifusion system, TGF- beta induced an immediate monotonic increase in insulin secretion. These results indicate that TGF- beta is a stimulator of insulin secretion.

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Year:  1989        PMID： 2645864     DOI： 10.1016/0006-291x(89)92829-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Effects of high dose retinoic acid on TGF-beta2 expression during pancreatic organogenesis.

Authors:  Neriman Colakoglu; Aysel Kukner; Jale Oner; M Fatih Sonmez; Hakan Oner; Enver Ozan
Journal:  J Mol Histol       Date:  2006-02-15       Impact factor: 2.611

2.  Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis.

Authors:  Melissa L Brown; Alan L Schneyer
Journal:  Trends Endocrinol Metab       Date:  2010-04-08       Impact factor: 12.015

3.  Differential synthesis and action of TGFß superfamily ligands in mouse and rat islets.

Authors:  Melissa L Brown; Fuminori Kimura; Lara M Bonomi; Nathan A Ungerleider; Alan L Schneyer
Journal:  Islets       Date:  2011-11-01       Impact factor: 2.694

Review 4.  Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer.

Authors:  Xiaojia Li; Jie He; Keping Xie
Journal:  Cell Oncol (Dordr)       Date:  2022-03-15       Impact factor: 6.730

5.  SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.

Authors:  Masatoshi Nomura; Hai-Lei Zhu; Lixiang Wang; Hidetaka Morinaga; Ryoichi Takayanagi; Noriyoshi Teramoto
Journal:  Diabetologia       Date:  2013-09-26       Impact factor: 10.122

6.  Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands.

Authors:  Haiya Wu; Karima Mezghenna; Patricia Marmol; Tingqing Guo; Annalena Moliner; Shao-Nian Yang; Per-Olof Berggren; Carlos F Ibáñez
Journal:  Diabetologia       Date:  2013-10-17       Impact factor: 10.122

Review 7.  TGF-β Signaling in Pancreatic Islet β Cell Development and Function.

Authors:  Ji-Hyun Lee; Ji-Hyeon Lee; Sushil G Rane
Journal:  Endocrinology       Date:  2021-03-01       Impact factor: 5.051

Review 8.  Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy.

Authors:  Gopika G Nair; Emmanuel S Tzanakakis; Matthias Hebrok
Journal:  Nat Rev Endocrinol       Date:  2020-06-25       Impact factor: 47.564

Review 9.  The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation.

Authors:  Yinan Jiang; Shane Fischbach; Xiangwei Xiao
Journal:  Int J Mol Sci       Date:  2018-10-12       Impact factor: 5.923

10.  TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation.

Authors:  Xiangwei Xiao; John Wiersch; Yousef El-Gohary; Ping Guo; Krishna Prasadan; Jose Paredes; Carey Welsh; Chiyo Shiota; George K Gittes
Journal:  Diabetes       Date:  2012-12-17       Impact factor: 9.461
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