Literature DB >> 26457518

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

Vidhyashankar Ramamurthy1, Aaron P Yamniuk2, Eric J Lawrence2, Wei Yong1, Lumelle A Schneeweis2, Lin Cheng2, Melissa Murdock2, Martin J Corbett2, Michael L Doyle2, Steven Sheriff1.   

Abstract

The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes. Consistent with the high sequence similarity between DR4 and DR5, the overall arrangement of the DR4-TRAIL complex does not differ substantially from that of the DR5-TRAIL complex. However, subtle differences are apparent. In addition, solution interaction studies were carried out that show differences in the thermodynamics of binding DR4 or DR5 with TRAIL.

Entities:  

Keywords:  TNF-related apoptosis-inducing ligand; death receptor 4; death receptor 5

Mesh：

Substances：

Year:  2015        PMID： 26457518      PMCID： PMC4601591          DOI： 10.1107/S2053230X15016416

Source DB:  PubMed          Journal:  Acta Crystallogr F Struct Biol Commun        ISSN： 2053-230X            Impact factor:   1.056


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