A C S Raposo1, R Ofri2, D P H Schaffer1, D C Gomes Júnior1, F A Libório3, E F Martins Filho4, A P Oriá1. 1. School of Veterinary Medicine and Zootechny, Federal University of Bahia UFBA, Salvador, BA, Brazil. 2. The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. 3. Screening Center for Wild Animals (CETAS), Salvador, BA, Brazil. 4. Faculdade de Ciências Agrárias e Veterinárias, UNESP, São Paulo State University, Jaboticabal, SP, Brazil.
Abstract
BACKGROUND: Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic parameters in 24 capuchin monkeys subjected to four dissociative anesthesia protocols. METHODS: Animals were anesthetized with tiletamine-zolazepam (TZ), ketamine-xylazine (KX), ketamine-midazolam (KM), or ketamine-dexmedetomidine (KD). Muscle relaxation, digital reflex, lacrimal production, intraocular pressure (IOP), heart and respiratory rates, oxygen saturation (SpO2 ), rectal temperature, non-invasive arterial blood pressure, palpebral and pupillary reflexes, and eyeball positioning were evaluated every 5 minutes for 20 minutes. RESULTS: Muscle relaxation was highest in KM and KD. At 5-minute post-injection, IOP was higher in TZ than in all other groups. There was a significant difference between groups and times in heart and respiratory rates and temperature. There were no significant differences in SpO2, arterial blood pressure, and lacrimal production between groups. CONCLUSIONS: The established parameters may help in clinical and ophthalmic examinations of primates.
BACKGROUND: Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic parameters in 24 capuchin monkeys subjected to four dissociative anesthesia protocols. METHODS: Animals were anesthetized with tiletamine-zolazepam (TZ), ketamine-xylazine (KX), ketamine-midazolam (KM), or ketamine-dexmedetomidine (KD). Muscle relaxation, digital reflex, lacrimal production, intraocular pressure (IOP), heart and respiratory rates, oxygen saturation (SpO2 ), rectal temperature, non-invasive arterial blood pressure, palpebral and pupillary reflexes, and eyeball positioning were evaluated every 5 minutes for 20 minutes. RESULTS: Muscle relaxation was highest in KM and KD. At 5-minute post-injection, IOP was higher in TZ than in all other groups. There was a significant difference between groups and times in heart and respiratory rates and temperature. There were no significant differences in SpO2, arterial blood pressure, and lacrimal production between groups. CONCLUSIONS: The established parameters may help in clinical and ophthalmic examinations of primates.
Authors: André B de Souza; Renan P S Rodrigues; Gerson T Pessoa; Andrezza Bs da Silva; Laecio S Moura; Francisco Ca Sousa; Elzivânia G da Silva; Anaemilia N Diniz; Maria Aps Barbosa; Jefferson R Araújo; Igor C Santos; Porfirio C Guerra; Jacyara Jrp Alves; Kássio V Macedo; Bruno Lm Diniz; Danielle C Marques; Flávio R Alves Journal: J Am Assoc Lab Anim Sci Date: 2018-01-01 Impact factor: 1.232