Literature DB >> 26456559

Cardiovascular Benefits of Dark Chocolate?

Erin Higginbotham1, Pam R Taub2.   

Abstract

OPINION STATEMENT: The use of cacao for health benefits dates back at least 3000 years. Our understanding of cacao has evolved with modern science. It is now felt based on extensive research the main health benefits of cacao stem from epicatechin, a flavanol found in cacao. The process of manufacturing dark chocolate retains epicatechin, whereas milk chocolate does not contain significant amounts of epicatechin. Thus, most of the current research studies are focused on dark chocolate. Both epidemiological and clinical studies suggest a beneficial effect of dark chocolate on blood pressure, lipids, and inflammation. Proposed mechanisms underlying these benefits include enhanced nitric oxide bioavailability and improved mitochondrial structure/function. Ultimately, further studies of this promising compound are needed to elucidate its potential for prevention and treatment of cardiovascular and metabolic diseases as well as other diseases that have underlying mechanisms of mitochondrial dysfunction and nitric oxide deficiency.

Entities:  

Keywords:  Cocoa; Dark chocolate; Epicatechin; Flavanols; Mitochondria; Skeletal muscle

Year:  2015        PMID: 26456559     DOI: 10.1007/s11936-015-0419-5

Source DB:  PubMed          Journal:  Curr Treat Options Cardiovasc Med        ISSN: 1092-8464


  37 in total

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Journal:  Circulation       Date:  2004-06-29       Impact factor: 29.690

2.  The pathobiology of diabetic complications: a unifying mechanism.

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Journal:  Diabetes       Date:  2005-06       Impact factor: 9.461

3.  Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study.

Authors:  Luc Djoussé; Paul N Hopkins; Donna K Arnett; James S Pankow; Ingrid Borecki; Kari E North; R Curtis Ellison
Journal:  Clin Nutr       Date:  2010-07-22       Impact factor: 7.324

4.  Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study.

Authors:  Luc Djoussé; Paul N Hopkins; Kari E North; James S Pankow; Donna K Arnett; R Curtis Ellison
Journal:  Clin Nutr       Date:  2010-09-19       Impact factor: 7.324

5.  (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle.

Authors:  Leonardo Nogueira; Israel Ramirez-Sanchez; Guy A Perkins; Anne Murphy; Pam R Taub; Guillermo Ceballos; Francisco J Villarreal; Michael C Hogan; Moh H Malek
Journal:  J Physiol       Date:  2011-07-25       Impact factor: 5.182

6.  The healthcare costs of sarcopenia in the United States.

Authors:  Ian Janssen; Donald S Shepard; Peter T Katzmarzyk; Ronenn Roubenoff
Journal:  J Am Geriatr Soc       Date:  2004-01       Impact factor: 5.562

7.  Simvastatin impairs exercise training adaptations.

Authors:  Catherine R Mikus; Leryn J Boyle; Sarah J Borengasser; Douglas J Oberlin; Scott P Naples; Justin Fletcher; Grace M Meers; Meghan Ruebel; M Harold Laughlin; Kevin C Dellsperger; Paul J Fadel; John P Thyfault
Journal:  J Am Coll Cardiol       Date:  2013-04-10       Impact factor: 24.094

8.  Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program.

Authors:  I Janszky; K J Mukamal; R Ljung; S Ahnve; A Ahlbom; J Hallqvist
Journal:  J Intern Med       Date:  2009-09       Impact factor: 8.989

9.  (-)Epigallocatechingallate protects the mitochondria against the deleterious effects of lipids, calcium and adenosine triphosphate in isoproterenol induced myocardial infarcted male Wistar rats.

Authors:  P T Devika; P Stanely Mainzen Prince
Journal:  J Appl Toxicol       Date:  2008-11       Impact factor: 3.446

10.  (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice.

Authors:  Icksoo Lee; Maik Hüttemann; Adele Kruger; Aliccia Bollig-Fischer; Moh H Malek
Journal:  Front Pharmacol       Date:  2015-03-13       Impact factor: 5.810

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  3 in total

1.  Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study.

Authors:  Elizabeth Mostofsky; Martin Berg Johansen; Anne Tjønneland; Harpreet S Chahal; Murray A Mittleman; Kim Overvad
Journal:  Heart       Date:  2017-05-23       Impact factor: 5.994

Review 2.  Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases-Promises, Perspectives, and Pitfalls.

Authors:  Anouk Kaulmann; Torsten Bohn
Journal:  Oxid Med Cell Longev       Date:  2016-07-10       Impact factor: 6.543

Review 3.  Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans.

Authors:  Luis Goya; María Ángeles Martín; Beatriz Sarriá; Sonia Ramos; Raquel Mateos; Laura Bravo
Journal:  Nutrients       Date:  2016-04-09       Impact factor: 5.717

  3 in total

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