Rebecca H Affoo1, Norine Foley2, Rushlee Garrick3, Walter L Siqueira4, Ruth E Martin1,5,6,7. 1. Graduate Program of Health and Rehabilitation Sciences, Western University, London, ON, Canada. 2. Brescia University College, Western University, London, ON, Canada. 3. Department of Psychology, Western University, London, ON, Canada. 4. Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. 5. Department of Physiology and Pharmacology, Western University, London, ON, Canada. 6. School of Communication Sciences and Disorders, Western University, London, ON, Canada. 7. Department of Otolaryngology, Western University, London, ON, Canada.
Abstract
OBJECTIVES: To determine whether salivary flow decreases as a function of aging. DESIGN: Meta-analysis. SETTING: Literature review. PARTICIPANTS: Individuals aged 18 and older reported to be free of major systemic disease. MEASUREMENTS: Relevant studies were identified through a literature search of several databases, from their inception to June 2013. Studies were included if saliva had been collected on at least one occasion in subjects aged 18 and older and if the data were presented in a manner that enabled comparisons of younger and older participants. Differences in salivary flow rates between age groups were calculated for each salivary source and condition and reported as standardized mean differences (SMDs), standard errors (SEs) and 95% confidence intervals (CIs). The results were pooled using a random effects model. A separate analysis examining medication use was also conducted. RESULTS: Forty-seven studies were included. Whole (SMD = 0.551, SE = 0.056, 95% CI = 0.423-0.678, P < .001) and submandibular and sublingual (SMSL) (SMD = 0.582, SE = 0.123, 95% CI = 0.341-0.823, P < .001) salivary flow rates were reduced significantly in older participants and in unstimulated and stimulated conditions. In contrast, parotid and minor gland salivary flow rates were not significantly reduced with increasing age. Additionally, unstimulated and stimulated SMSL, and unstimulated whole salivary flow rates were significantly lower in older adults, regardless of medication usage. CONCLUSION: The aging process is associated with reduced salivary flow in a salivary-gland-specific manner; this reduction in salivary flow cannot be explained on the basis of medications. These findings have important clinical implications for maintaining optimal oral health in older adults.
OBJECTIVES: To determine whether salivary flow decreases as a function of aging. DESIGN: Meta-analysis. SETTING: Literature review. PARTICIPANTS: Individuals aged 18 and older reported to be free of major systemic disease. MEASUREMENTS: Relevant studies were identified through a literature search of several databases, from their inception to June 2013. Studies were included if saliva had been collected on at least one occasion in subjects aged 18 and older and if the data were presented in a manner that enabled comparisons of younger and older participants. Differences in salivary flow rates between age groups were calculated for each salivary source and condition and reported as standardized mean differences (SMDs), standard errors (SEs) and 95% confidence intervals (CIs). The results were pooled using a random effects model. A separate analysis examining medication use was also conducted. RESULTS: Forty-seven studies were included. Whole (SMD = 0.551, SE = 0.056, 95% CI = 0.423-0.678, P < .001) and submandibular and sublingual (SMSL) (SMD = 0.582, SE = 0.123, 95% CI = 0.341-0.823, P < .001) salivary flow rates were reduced significantly in older participants and in unstimulated and stimulated conditions. In contrast, parotid and minor gland salivary flow rates were not significantly reduced with increasing age. Additionally, unstimulated and stimulated SMSL, and unstimulated whole salivary flow rates were significantly lower in older adults, regardless of medication usage. CONCLUSION: The aging process is associated with reduced salivary flow in a salivary-gland-specific manner; this reduction in salivary flow cannot be explained on the basis of medications. These findings have important clinical implications for maintaining optimal oral health in older adults.
Authors: C Muñoz-González; M Vandenberghe-Descamps; G Feron; F Canon; H Labouré; C Sulmont-Rossé Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Oliver M Shannon; Chris Easton; Anthony I Shepherd; Mario Siervo; Stephen J Bailey; Tom Clifford Journal: BMC Sports Sci Med Rehabil Date: 2021-06-07