Literature DB >> 26455435

Cutaneous ulcers in a returning traveller: a rare case of imported diphtheria in the UK.

T G Nelson1, C D Mitchell1, G M Sega-Hall1, R J Porter2.   

Abstract

We describe a case of cutaneous diphtheria in the UK, presenting as lower leg ulcers in a returning traveller, and discuss the epidemiology, significance and public health implications of this disease and the therapeutic options available. A 65-year-old woman presented with a 6-week history of multiple ulcers appearing on her legs following a holiday in Kenya. Culture of biopsy tissue grew Corynebacterium diphtheriae. A cascade of therapeutic and public health interventions followed, many of which were terminated once the isolate was confirmed as nontoxigenic. Cutaneous diphtheria is a rare, notifiable disease in the UK, but is common in tropical countries, and is most often seen in the West as a traveller's disease. Corynebacteria are common skin commensals, and without appropriate clinical details, laboratories may not recognize C. diphtheriae/Corynebacterium ulcerans. This is likely to have led to under-reporting and under-recognition of the condition.
© 2015 British Association of Dermatologists.

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Year:  2015        PMID: 26455435     DOI: 10.1111/ced.12763

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN: 0307-6938            Impact factor:   3.470


  4 in total

1.  Zoonotic Transmission of Diphtheria from Domestic Animal Reservoir, Spain.

Authors:  Andreas Hoefer; Silvia Herrera-León; Lucas Domínguez; Maria Ordobás Gavín; Beatriz Romero; Ximena Belen Araujo Piedra; Cristina Sobrino Calzada; María José Uría González; Laura Herrera-León
Journal:  Emerg Infect Dis       Date:  2022-06       Impact factor: 16.126

2.  Molecular and Epidemiological Characterization of Toxigenic and Nontoxigenic Corynebacterium diphtheriae, Corynebacterium belfantii, Corynebacterium rouxii, and Corynebacterium ulcerans Isolates Identified in Spain from 2014 to 2019.

Authors:  Andreas Hoefer; Despina Pampaka; Silvia Herrera-León; Sonia Peiró; Sarai Varona; Noemí López-Perea; Josefa Masa-Calles; Laura Herrera-León
Journal:  J Clin Microbiol       Date:  2021-02-18       Impact factor: 5.948

3.  Increasing prevalence of infectious diseases in asylum seekers at a tertiary care hospital in Switzerland.

Authors:  Constantine Bloch-Infanger; Veronika Bättig; Jürg Kremo; Andreas F Widmer; Adrian Egli; Roland Bingisser; Manuel Battegay; Stefan Erb
Journal:  PLoS One       Date:  2017-06-15       Impact factor: 3.240

Review 4.  Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings.

Authors:  Helena M B Seth-Smith; Adrian Egli
Journal:  Front Public Health       Date:  2019-08-21
  4 in total

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