| Literature DB >> 26454624 |
Raoul Saggini1, Andrea Saggini2, Anna Maria Spagnoli3, Ira Dodaj4, Emanuele Cigna3, Michele Maruccia3, Giuseppe Soda3, Rosa Grazia Bellomo5, Nicolò Scuderi3.
Abstract
Prolonged and abnormal scarring after trauma, burns and surgical procedures often results in a pathologic scar. We evaluated the efficacy of unfocused shock wave treatment, alone or in combination with manual therapy, on retracting scars on the hands. Scar appearance was assessed by means of the modified Vancouver Scar Scale; functional hand mobility was evaluated using a range-of-motion scale, whereas a visual analogue score was implemented for detecting any improvements in referred pain. Additionally, biopsy specimens were collected for clinico-pathologic correlation. For each active treatment group, statistically significant improvements in modified Vancouver Scar Scale were recorded as early as five treatment sessions and confirmed 2 wk after the last treatment session. Analogous results were observed when assessing pain and range of movement. Histopathological examination revealed significant increases in dermal fibroblasts in each active treatment group, as well as in neoangiogenetic response and type-I collagen concentration.Entities:
Keywords: Collagen; ESWT; Histopathologic features; Regeneration; Resolution; Retracting scar; Scarring
Mesh:
Year: 2015 PMID: 26454624 DOI: 10.1016/j.ultrasmedbio.2015.07.028
Source DB: PubMed Journal: Ultrasound Med Biol ISSN: 0301-5629 Impact factor: 2.998