| Literature DB >> 26454417 |
Laetitia Guillemette1, Marilyn Lacroix1, Catherine Allard2, Julie Patenaude1, Marie-Claude Battista1, Myriam Doyon3, Julie Moreau3, Julie Ménard3, Jean-Luc Ardilouze4, Patrice Perron4, Anne-Marie Côté4, Marie-France Hivert5.
Abstract
Hypertensive disorders of pregnancy (HDP) lead to high rates of maternal and fetal morbidity. Existing studies on inflammatory marker TNFα in HDP offspring are inconsistent. We performed a population-based cohort study of 636 pregnancies, including normotensive (NT) women and women with preeclampsia (PE) or gestational hypertension (GH). TNFα was measured in maternal blood in the first and second trimesters and in cord blood at the time of delivery. Cord blood TNFα was higher in offspring delivered of women with PE (6.53 [4.94-8.38]pg/mL) versus those delivered of NT women (5.13 [4.11-6.72]pg/mL; p=0.01), independent of confounders. Maternal TNFα levels were not different among groups (p>0.1) in either the first or second trimester.Entities:
Keywords: Gestational hypertension; Preeclampsia; TNFα; Umbilical cord
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Year: 2015 PMID： 26454417 DOI： 10.1016/j.jri.2015.09.003
Source DB: PubMed Journal: J Reprod Immunol ISSN： 0165-0378 Impact factor: 4.054