Adir Farhi1, Arnon D Cohen2, Ora Shovman1, Doron Comaneshter3, Howard Amital4, Daniela Amital5. 1. Department of Medicine 'B', Zabludowicz center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. 2. Chief Physician's Office, Clalit Health Services Tel Aviv, Ben Gurion University of the Negev, Beer Sheva, Israel; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. 3. Chief Physician's Office, Clalit Health Services Tel Aviv, Ben Gurion University of the Negev, Beer Sheva, Israel. 4. Department of Medicine 'B', Zabludowicz center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: howard.amital@sheba.health.gov.il. 5. Sackler Faculty of Medicine, Tel-Aviv University, Israel; Ness Ziona Beer-Yaacov Mental Health Center, Israel.
Abstract
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with systemic comorbidities. Recent data suggests that patients with RA have increased prevalence of the bipolar disorder. The current study investigates the association between RA and bipolar disorder. METHODS: A case-control study was conducted as Patients with RA were compared with age- and gender-matched controls regarding the prevalence of bipolar disorder. Pearson χ(2) test was used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. RESULTS: The study included 11,782 patients with RA and 57,973 age- and gender-matched controls. The prevalence of Bipolar disorder in patients with RA was increased compared with the prevalence in controls (0.6% and 0.4% respectively, p=0.036). However, in a multivariate analysis the association between RA and Bipolar disorder was not significant, whereas smoking is positively correlated with Bipolar disorder (p<0.001). CONCLUSIONS: By univariate analysis our data implied that patients with RA have a greater prevalence of bipolar disorder than matched controls. However, our analysis suggests that this association may have been confounded by smoking status. Further research is warranted before making inferences about this association in the level of clinical practice.
BACKGROUND:Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with systemic comorbidities. Recent data suggests that patients with RA have increased prevalence of the bipolar disorder. The current study investigates the association between RA and bipolar disorder. METHODS: A case-control study was conducted as Patients with RA were compared with age- and gender-matched controls regarding the prevalence of bipolar disorder. Pearson χ(2) test was used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. RESULTS: The study included 11,782 patients with RA and 57,973 age- and gender-matched controls. The prevalence of Bipolar disorder in patients with RA was increased compared with the prevalence in controls (0.6% and 0.4% respectively, p=0.036). However, in a multivariate analysis the association between RA and Bipolar disorder was not significant, whereas smoking is positively correlated with Bipolar disorder (p<0.001). CONCLUSIONS: By univariate analysis our data implied that patients with RA have a greater prevalence of bipolar disorder than matched controls. However, our analysis suggests that this association may have been confounded by smoking status. Further research is warranted before making inferences about this association in the level of clinical practice.
Authors: Abdulla Watad; Arsalan Abu Much; Danielle Bracco; Naim Mahroum; Doron Comaneshter; Arnon D Cohen; Howard Amital Journal: Immunol Res Date: 2017-04 Impact factor: 2.829
Authors: S Tiosano; A Farhi; A Watad; N Grysman; R Stryjer; H Amital; D Comaneshter; A D Cohen; D Amital Journal: Epidemiol Psychiatr Sci Date: 2016-07-26 Impact factor: 6.892
Authors: Ruth Ann Marrie; Carol A Hitchon; Randy Walld; Scott B Patten; James M Bolton; Jitender Sareen; John R Walker; Alexander Singer; Lisa M Lix; Renée El-Gabalawy; Alan Katz; John D Fisk; Charles N Bernstein Journal: Arthritis Care Res (Hoboken) Date: 2018-05-21 Impact factor: 4.794