Literature DB >> 26453586

Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in a Patient with Chronic Granulomatous Disease and Active Infection: A First Report.

Mark Parta1, Dianne Hilligoss2, Corin Kelly2, Nana Kwatemaa2, Narda Theobald2, Harry Malech2, Elizabeth M Kang2.   

Abstract

PURPOSE: We describe haploidentical hematopoietic cell transplantation (HCT) with high-dose post-transplant cyclophosphamide (PTCy) in a boy with x-linked chronic granulomatous disease (CGD).
METHODS: A persistent and life-threatening fungal infection was the indication for HSCT. Non-myeloablative conditioning with PTCy (50 mg/kg days 3 and 4) was used in the absence of fully matched donors.
RESULTS: Engraftment occurred on day 24. The patient experienced Grade 2 graft-versus-host disease of the skin and gastrointestinal tract and CMV infection, both of which were controlled. Chimerism was 100 % at days 30 and 6 months. Cessation of antifungal therapy was consistent with cure of the infection.
CONCLUSIONS: Haploidentical HCT with high-dose PTCy for CGD is feasible and succeeded even in the context of active infection.

Entities:  

Keywords:  Chronic granulomatous disease; graft versus host disease; haploidentical; hematopoietic cell transplantation; post-transplant cyclophosphamide; scedosporium apiospermum

Mesh：

Substances：

Year:  2015        PMID： 26453586      PMCID： PMC6317348          DOI： 10.1007/s10875-015-0204-y

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  36 in total

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4.  Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide.

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6.  Diagnostic and therapeutic impact of whole body positron emission tomography using fluorine-18-fluoro-2-deoxy-D-glucose in children with chronic granulomatous disease.

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  15 in total

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Review 2.  Enzymatic Mechanisms Involved in Evasion of Fungi to the Oxidative Stress: Focus on Scedosporium apiospermum.

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4.  Successful Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide in a Severe Combined Immune Deficiency Patient: a First Report.

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Review 6.  Infectious Complications in Patients With Chronic Granulomatous Disease.

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7.  Transplantation of Hematopoietic Stem Cells for Primary Immunodeficiencies in Brazil: Challenges in Treating Rare Diseases in Developing Countries.

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Journal:  J Clin Immunol       Date:  2018-11-24       Impact factor: 8.317

8.  Failure to Prevent Severe Graft-Versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in Chronic Granulomatous Disease.

Authors:  Mark Parta; Dianne Hilligoss; Corin Kelly; Nana Kwatemaa; Narda Theobald; Christa S Zerbe; Steven M Holland; Harry L Malech; Elizabeth M Kang
Journal:  J Clin Immunol       Date:  2020-04-20       Impact factor: 8.317

Review 9.  T Cell-Depleted and T Cell-Replete HLA-Haploidentical Stem Cell Transplantation for Non-malignant Disorders.

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