Literature DB >> 26453157

Recent developments in ocular drug delivery.

Hongming Chen1.   

Abstract

Ocular drug delivery has many challenges due to the inherent physiology and natural barriers. Traditionally used eye drops are fairly inefficient with low ocular bioavailability, and drug delivery to the back of the eye currently requires invasive measures, such as implants or frequent intravitreal injections. These challenges, however, present unique opportunities for innovative drug delivery approaches. This review highlights several of these approaches, with special emphasis on those progressing in clinical development.

Keywords:  Cell and gene therapy; contact lens; implants; iontophoresis; particulates; posterior; punctal plug; topical inserts

Mesh：

Substances：

Year:  2015        PMID： 26453157     DOI： 10.3109/1061186X.2015.1052073

Source DB:  PubMed          Journal:  J Drug Target        ISSN： 1026-7158            Impact factor:   5.121


  5 in total

1.  A flexible device for ocular iontophoretic drug delivery.

Authors:  Yushi Zhang; Yao Chen; Xiaoxue Yu; Yangjia Qi; Yufeng Chen; Yuxi Liu; Yuntao Hu; Zhihong Li
Journal:  Biomicrofluidics       Date:  2016-02-24       Impact factor: 2.800

2.  A Hydrogel Ionic Circuit Based High-Intensity Iontophoresis Device for Intraocular Macromolecule and Nanoparticle Delivery.

Authors:  Fan Zhao; Shan Fan; Deepta Ghate; Svetlana Romanova; Tatiana K Bronich; Siwei Zhao
Journal:  Adv Mater       Date:  2021-12-08       Impact factor: 30.849

3.  Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs.

Authors:  Charles Blizzard; Ankita Desai; Arthur Driscoll
Journal:  J Ocul Pharmacol Ther       Date:  2016-08-02       Impact factor: 2.671

Review 4.  Dexamethasone 0.4mg Sustained-Release Intracanalicular Insert in the Management of Ocular Inflammation and Pain Following Ophthalmic Surgery: Design, Development and Place in Therapy.

Authors:  Cassandra C Brooks; Sayena Jabbehdari; Preeya K Gupta
Journal:  Clin Ophthalmol       Date:  2020-01-13

Review 5.  New Perspectives for Eye-Sparing Treatment Strategies in Primary Uveal Melanoma.

Authors:  Krzysztof Bilmin; Kamil J Synoradzki; Anna M Czarnecka; Mateusz J Spałek; Tamara Kujawska; Małgorzata Solnik; Piotr Merks; Mario Damiano Toro; Robert Rejdak; Michał Fiedorowicz
Journal:  Cancers (Basel)       Date:  2021-12-28       Impact factor: 6.639
  5 in total

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