Correlation between beat-to-beat blood pressure variability and arterial stiffness in healthy adults in the cold pressor test.

Blood pressure variability has a great effect on the progression of arterial stiffness, which has increasingly become a hot research topic recently. In this study, beat-to-beat recordings of blood pressure (BP), heart rate, cardiac output, total peripheral resistance, and left ventricular ejection time during the cold pressor test (CPT) were analyzed together. We recruited 101 young Chinese subjects (aged 21-33) with no known history of high BP into the study. We found that the mean level of beat-to-beat BP and the average real variability and successive variation of beat-to-beat diastolic BP variability in the CPT showed significant correlations with pulse wave velocity (PWV) (r = 0.22-0.34, P < 0.05). In addition, we also found correlations between beat-to-beat heart rate and heart rate variability indices and PWV in each phase of the CPT. At the same time, the standard deviation of the R-R intervals and square root of the mean squared difference of successive R-R intervals in the cold stimulus phase also showed significant correlations with PWV (r = 0.23-0.24, P < 0.05). In conclusion, the level and variability of beat-to-beat BP have a strong influence on arterial stiffness.