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Literature DB >> 26452359

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

Rafael Franco^1,2, Verònica Casadó-Anguera^3,4, Ana Muñoz^3,5, Milos Petrovic^6,7, Gemma Navarro^3,4, Estefanía Moreno^3,4, José Luis Lanciego^3,8, José Luis Labandeira-García^3,5, Antoni Cortés^3,4, Vicent Casadó^3,4.

Abstract

Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.

Entities: Chemical Disease Gene Species

Keywords: 6-hydroxydopamine; Basal ganglia; Cooperativity index; Dyskinesia; G-protein-coupled receptor dimer; Lateralization

Mesh：

Substances：

Year: 2015 PMID： 26452359 DOI： 10.1007/s12035-015-9468-8

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

49 in total

1. Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance.

Authors: G Nikkhah; G Falkenstein; C Rosenthal
Journal: J Neurosci Date: 2001-08-15 Impact factor: 6.167

2. Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors.

Authors: Chiara Fiorentini; Fabrizio Gardoni; PierFranco Spano; Monica Di Luca; Cristina Missale
Journal: J Biol Chem Date: 2003-03-19 Impact factor: 5.157

Review 3. Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

Authors: Vincent Casadó; Antoni Cortés; Francisco Ciruela; Josefa Mallol; Sergi Ferré; Carmen Lluis; Enric I Canela; Rafael Franco
Journal: Pharmacol Ther Date: 2007-06-14 Impact factor: 12.310

4. Activation of the D1 receptors inhibits the long-term potentiation in vivo induced by acute morphine administration through a D1-GluN2A interaction in the nucleus accumbens.

Authors: Qiaohua Zheng; Zhiqiang Liu; Chunling Wei; Jing Han; Yihui Liu; Xia Zhang; Wei Ren
Journal: Neuroreport Date: 2014-10-22 Impact factor: 1.837

5. From unilateral to bilateral parkinsonism: Effects of lateralization on dyskinesias and associated molecular mechanisms.

Authors: C Marin; M Bonastre; G Mengod; R Cortés; M C Rodríguez-Oroz
Journal: Neuropharmacology Date: 2015-06-22 Impact factor: 5.250

6. Dopaminergic lateralisation in the forebrain: relations to behavioural asymmetries and anxiety in male Wistar rats.

Authors: C M Thiel; R K Schwarting
Journal: Neuropsychobiology Date: 2001 Impact factor: 2.328

7. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

Authors: Lauren T May; Lloyd J Bridge; Leigh A Stoddart; Stephen J Briddon; Stephen J Hill
Journal: FASEB J Date: 2011-06-29 Impact factor: 5.191

Review 2. Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.

Authors: Thérèse van Amelsvoort; Dennis Hernaus
Journal: Front Psychiatry Date: 2016-05-18 Impact factor: 4.157

2 in total

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

1. Restorative plasticity of dopamine neuronal transplants depends on the degree of hemispheric dominance.

2. Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors.

Review 3. Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

4. Activation of the D1 receptors inhibits the long-term potentiation in vivo induced by acute morphine administration through a D1-GluN2A interaction in the nucleus accumbens.

5. From unilateral to bilateral parkinsonism: Effects of lateralization on dyskinesias and associated molecular mechanisms.

6. Dopaminergic lateralisation in the forebrain: relations to behavioural asymmetries and anxiety in male Wistar rats.

7. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

8. Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal.

9. Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.

10. Dopamine D3 receptor is decreased and D2 receptor is elevated in the striatum of Parkinson's disease.

1. Nicotine Effects on White Matter Microstructure in Young Adults.

Review 2. Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.