BACKGROUND: Obesity is a major risk factor in the development of hepatic insulin resistance, which is characterized by an impairment of insulin ability to inhibit glucose output. Although the underlying mechanism for the link between obesity and insulin resistance in the liver is unclear, it has been widely reported and suggested that hepatic endoplasmic reticulum (ER) stress and inflammation induced by obesity lead to the development of hepatic insulin resistance and gluconeogenesis. SUMMARY: This review addresses the aspects of ER stress and inflammation currently understood to be involved in metabolic disease, including their role in obesity, hepatic insulin resistance, and hyperglycemia.
BACKGROUND:Obesity is a major risk factor in the development of hepatic insulin resistance, which is characterized by an impairment of insulin ability to inhibit glucose output. Although the underlying mechanism for the link between obesity and insulin resistance in the liver is unclear, it has been widely reported and suggested that hepatic endoplasmic reticulum (ER) stress and inflammation induced by obesity lead to the development of hepatic insulin resistance and gluconeogenesis. SUMMARY: This review addresses the aspects of ER stress and inflammation currently understood to be involved in metabolic disease, including their role in obesity, hepatic insulin resistance, and hyperglycemia.
Authors: C Bañuls; S Rovira-Llopis; S Lopez-Domenech; N Diaz-Morales; A Blas-Garcia; S Veses; C Morillas; V M Victor; M Rocha; A Hernandez-Mijares Journal: Int J Obes (Lond) Date: 2017-06-20 Impact factor: 5.095
Authors: Manush Saydmohammed; Anupma Jha; Vineet Mahajan; Dillon Gavlock; Tong Ying Shun; Richard DeBiasio; Daniel Lefever; Xiang Li; Celeste Reese; Erin E Kershaw; Vijay Yechoor; Jaideep Behari; Alejandro Soto-Gutierrez; Larry Vernetti; Andrew Stern; Albert Gough; Mark T Miedel; D Lansing Taylor Journal: Exp Biol Med (Maywood) Date: 2021-05-06
Authors: Ji Won Jeong; Bonggi Lee; Dae Hyun Kim; Hyoung Oh Jeong; Kyoung Mi Moon; Min Jo Kim; Takako Yokozawa; Hae Young Chung Journal: Molecules Date: 2018-08-21 Impact factor: 4.411