| Literature DB >> 26451743 |
Sangram K Samal1,2,3, Vitaly Goranov1, Mamoni Dash4, Alessandro Russo5, Tatiana Shelyakova5, Patrizio Graziosi1, Lisa Lungaro1,6, Alberto Riminucci1, Marc Uhlarz7, Manuel Bañobre-López8, Jose Rivas9, Thomas Herrmannsdörfer7, Jayakumar Rajadas10, Stefaan De Smedt3, Kevin Braeckmans3, David L Kaplan2, V Alek Dediu1.
Abstract
A versatile approach for the design and fabrication of multilayer magnetic scaffolds with tunable magnetic gradients is described. Multilayer magnetic gelatin membrane scaffolds with intrinsic magnetic gradients were designed to encapsulate magnetized bioagents under an externally applied magnetic field for use in magnetic-field-assisted tissue engineering. The temperature of the individual membranes increased up to 43.7 °C under an applied oscillating magnetic field for 70 s by magnetic hyperthermia, enabling the possibility of inducing a thermal gradient inside the final 3D multilayer magnetic scaffolds. On the basis of finite element method simulations, magnetic gelatin membranes with different concentrations of magnetic nanoparticles were assembled into 3D multilayered scaffolds. A magnetic-gradient-controlled distribution of magnetically labeled stem cells was demonstrated in vitro. This magnetic biomaterial-magnetic cell strategy can be expanded to a number of different magnetic biomaterials for various tissue engineering applications.Entities:
Keywords: biomaterials; gelatin; gradient; magnetic; nanoparticles; scaffold; tissue engineering
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Year: 2015 PMID： 26451743 PMCID： PMC4867029 DOI： 10.1021/acsami.5b06813
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229