Karolina Leopold1, Andreas Reif2, Sarah Haack1, Michael Bauer1, Daniel Bury3, Antje Löffler1, Sarah Kittel-Schneider2, Steffi Pfeiffer1, Cathrin Sauer1, Peter Schwarz4, Andrea Pfennig5. 1. Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Germany. 2. Department of Psychiatry and Psychotherapy, University Hospital Würzburg, Germany; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt/Main, Germany. 3. Department of Psychiatry and Psychotherapy, University Hospital Würzburg, Germany. 4. Department of Internal Medicine, Carl Gustav Carus University Hospital, Technische Universität Dresden, Germany. 5. Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Germany. Electronic address: andrea.pfennig@uniklinikum-dresden.de.
Abstract
BACKGROUND: Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not clear. METHODS: 85 euthymic outpatients with bipolar disorders from two university hospitals in Germany underwent an oral glucose tolerance test, laboratory screening and clinical measurements. Socio-demographic data, medication, severity of illness, global functioning and life quality were assessed. RESULTS: Diabetes mellitus was found in 7% of the patients, pre-diabetic abnormalities in 27%. The group of patients with abnormalities in the glucose metabolism had significantly lower quality of life and global functioning. Higher BMI, leptin, triglycerides and CRP levels significantly increased the likelihood for pre-diabetes/diabetes. LIMITATIONS: The low sample size did only allow limited assessment of impact of medication on the results. No healthy controls were assessed. CONCLUSIONS: One-third of the patients with bipolar disorders showed abnormalities in the glucose metabolism and this was associated with impaired global functioning and lower quality of life. Early detection and intervention strategies fitting the needs of patient with bipolar disorder are needed to improve both physical and mental health.
BACKGROUND:Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not clear. METHODS: 85 euthymic outpatients with bipolar disorders from two university hospitals in Germany underwent an oral glucose tolerance test, laboratory screening and clinical measurements. Socio-demographic data, medication, severity of illness, global functioning and life quality were assessed. RESULTS:Diabetes mellitus was found in 7% of the patients, pre-diabetic abnormalities in 27%. The group of patients with abnormalities in the glucose metabolism had significantly lower quality of life and global functioning. Higher BMI, leptin, triglycerides and CRP levels significantly increased the likelihood for pre-diabetes/diabetes. LIMITATIONS: The low sample size did only allow limited assessment of impact of medication on the results. No healthy controls were assessed. CONCLUSIONS: One-third of the patients with bipolar disorders showed abnormalities in the glucose metabolism and this was associated with impaired global functioning and lower quality of life. Early detection and intervention strategies fitting the needs of patient with bipolar disorder are needed to improve both physical and mental health.
Authors: Joanne H Huang; Shaunna S Berkovitch; Jonathan Iaconelli; Bradley Watmuff; Hyoungjun Park; Shrikanta Chattopadhyay; Donna McPhie; Dost Öngür; Bruce M Cohen; Clary B Clish; Rakesh Karmacharya Journal: Mol Neuropsychiatry Date: 2016-06-24
Authors: Sarah Kittel-Schneider; Daniel Bury; Karolina Leopold; Sara Haack; Michael Bauer; Steffi Pfeiffer; Cathrin Sauer; Andrea Pfennig; Henry Völzke; Hans-Jörgen Grabe; Andreas Reif Journal: Front Psychiatry Date: 2020-04-22 Impact factor: 4.157