Literature DB >> 26451314

TLR activation and ionizing radiation induce strong immune responses against multiple tumor entities.

Sebastian Schölch1, Conrad Rauber2, Jürgen Weitz3, Moritz Koch3, Peter E Huber4.   

Abstract

Toll-like receptor (TLR) 7/8 ligands act together with radiotherapy and induce profound systemic antitumor immune reactions coordinated by dendritic cells and executed by natural killer (NK) and cytotoxic T cells. Combining TLR ligands and radiation improves both local and distant tumor control and has been shown to be effective against multiple tumor entities.

Entities:  

Keywords:  GI tumors; TLR7/8 ligand; Toll-like receptor; colorectal cancer; immunotherapy; pancreatic cancer; radiotherapy

Year:  2015        PMID： 26451314      PMCID： PMC4589041          DOI： 10.1080/2162402X.2015.1042201

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Antiviral applications of Toll-like receptor agonists.

Authors:  Nigel J Horscroft; David C Pryde; Helen Bright
Journal:  J Antimicrob Chemother       Date:  2012-01-18       Impact factor: 5.790

2.  Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.

Authors:  Felix Klug; Hridayesh Prakash; Peter E Huber; Tobias Seibel; Noemi Bender; Niels Halama; Christina Pfirschke; Ralf Holger Voss; Carmen Timke; Ludmila Umansky; Kay Klapproth; Knut Schäkel; Natalio Garbi; Dirk Jäger; Jürgen Weitz; Hubertus Schmitz-Winnenthal; Günter J Hämmerling; Philipp Beckhove
Journal:  Cancer Cell       Date:  2013-10-24       Impact factor: 31.743

3.  Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.

Authors:  Fiona Bath-Hextall; Mara Ozolins; Sarah J Armstrong; Graham B Colver; William Perkins; Paul S J Miller; Hywel C Williams
Journal:  Lancet Oncol       Date:  2013-12-11       Impact factor: 41.316

4.  In situ photoimmunotherapy: a tumour-directed treatment for melanoma.

Authors:  M F Naylor; W R Chen; T K Teague; L A Perry; R E Nordquist
Journal:  Br J Dermatol       Date:  2006-12       Impact factor: 9.302

Review 5.  Taking dendritic cells into medicine.

Authors:  Ralph M Steinman; Jacques Banchereau
Journal:  Nature       Date:  2007-09-27       Impact factor: 49.962

6.  Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy.

Authors:  Guido Kroemer; Laurence Zitvogel
Journal:  Oncoimmunology       Date:  2012-07-01       Impact factor: 8.110

7.  Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors.

Authors:  Sebastian Schölch; Conrad Rauber; Alexandra Tietz; Nuh N Rahbari; Ulrich Bork; Thomas Schmidt; Christoph Kahlert; Uwe Haberkorn; Mark A Tomai; Kenneth E Lipson; Rafael Carretero; Jürgen Weitz; Moritz Koch; Peter E Huber
Journal:  Oncotarget       Date:  2015-03-10

Review 8.  Trial Watch: Anticancer radioimmunotherapy.

Authors:  Erika Vacchelli; Ilio Vitale; Eric Tartour; Alexander Eggermont; Catherine Sautès-Fridman; Jérôme Galon; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2013-07-03       Impact factor: 8.110

9.  A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.

Authors:  Amy L Adlard; Simon J Dovedi; Brian A Telfer; Erina Koga-Yamakawa; Charlotte Pollard; Jamie Honeychurch; Timothy M Illidge; Masashi Murata; David T Robinson; Philip J Jewsbury; Robert W Wilkinson; Ian J Stratford
Journal:  Int J Cancer       Date:  2014-01-17       Impact factor: 7.396

10.  Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma.

Authors:  Simon J Dovedi; Monique H M Melis; Robert W Wilkinson; Amy L Adlard; Ian J Stratford; Jamie Honeychurch; Timothy M Illidge
Journal:  Blood       Date:  2012-10-18       Impact factor: 22.113
  10 in total
  14 in total

1.  The age-dependent effect of high-dose X-ray radiation on NFκB signaling, structure, and mechanical behavior of the intervertebral disc.

Authors:  Jennifer W Liu; Sytse Piersma; Simon Y Tang
Journal:  Connect Tissue Res       Date:  2019-12-26       Impact factor: 3.417

2.  Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer.

Authors:  Susan Kochall; May-Linn Thepkaysone; Sebastián A García; Alexander M Betzler; Jürgen Weitz; Christoph Reissfelder; Sebastian Schölch
Journal:  J Vis Exp       Date:  2017-07-18       Impact factor: 1.355

Review 3.  The Role of Toll-like Receptor Agonists and Their Nanomedicines for Tumor Immunotherapy.

Authors:  Lingling Huang; Xiaoyan Ge; Yang Liu; Hui Li; Zhiyue Zhang
Journal:  Pharmaceutics       Date:  2022-06-10       Impact factor: 6.525

4.  An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models.

Authors:  Ela Markovsky; Sadna Budhu; Robert M Samstein; Hongyan Li; James Russell; Zhigang Zhang; Esther Drill; Chloe Bodden; Qing Chen; Simon N Powell; Taha Merghoub; Jedd D Wolchok; John Humm; Joseph O Deasy; Adriana Haimovitz-Friedman
Journal:  Int J Radiat Oncol Biol Phys       Date:  2018-10-18       Impact factor: 7.038

Review 5.  Cancer immunotherapy: how low-level ionizing radiation can play a key role.

Authors:  Marek K Janiak; Marta Wincenciak; Aneta Cheda; Ewa M Nowosielska; Edward J Calabrese
Journal:  Cancer Immunol Immunother       Date:  2017-03-30       Impact factor: 6.968

Review 6.  Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways.

Authors:  Kai Li; Shuai Qu; Xi Chen; Qiong Wu; Ming Shi
Journal:  Int J Mol Sci       Date:  2017-02-14       Impact factor: 5.923

7.  Radiation induces changes in toll-like receptors of the uterine cervix of the rat.

Authors:  Marie Francoise Mukanyangezi; Lucie Podmolíková; Wurood Al Hydad; Gunnar Tobin; Daniel Giglio
Journal:  PLoS One       Date:  2019-04-18       Impact factor: 3.240

Review 8.  Immune targets in the tumor microenvironment treated by radiotherapy.

Authors:  Omer M Ozpiskin; Lu Zhang; Jian Jian Li
Journal:  Theranostics       Date:  2019-01-30       Impact factor: 11.556

9.  Inflammation and tumor progression: signaling pathways and targeted intervention.

Authors:  Huakan Zhao; Lei Wu; Guifang Yan; Yu Chen; Mingyue Zhou; Yongzhong Wu; Yongsheng Li
Journal:  Signal Transduct Target Ther       Date:  2021-07-12

10.  Targeting the Innate Immune Kinase IRAK1 in Radioresistant Cancer: Double-Edged Sword or One-Two Punch?

Authors:  Peter H Liu; Samuel Sidi
Journal:  Front Oncol       Date:  2019-11-13       Impact factor: 6.244
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