Literature DB >> 26450581

Incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease among community-dwelling persons.

Marjaana Koponen1, Anna-Maija Tolppanen2, Heidi Taipale2, Antti Tanskanen2, Jari Tiihonen2, Kristina Johnell2, Johan Fastbom2, Riitta Ahonen2, Sirpa Hartikainen2.   

Abstract

BACKGROUND: Behavioural and psychological symptoms of dementia are frequently treated with antipsychotics. AIMS: To determine the incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease.
METHOD: Cohort of all community-dwellers in Finland diagnosed with Alzheimer's disease in 2005 and matched controls. All antipsychotics dispensed between 1995 and 2009 were extracted from the Finnish National Prescription Register.
RESULTS: Altogether 1996/6087 (32.8%) persons with Alzheimer's disease initiated antipsychotic use. The incidence of antipsychotic use was fivefold among persons with Alzheimer's disease compared with controls, started to increase 2-3 years before diagnosis and was highest during the first 6 months after diagnosis.
CONCLUSIONS: A distinct increase in antipsychotic initiations occurs in the same time window as Alzheimer's disease diagnosis. © The Royal College of Psychiatrists 2015.

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Year:  2015        PMID: 26450581     DOI: 10.1192/bjp.bp.114.162834

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  5 in total

1.  The Impact of Dementia Diagnosis on Patterns of Potentially Inappropriate Medication Use Among Older Adults.

Authors:  Danijela Gnjidic; George O Agogo; Christine M Ramsey; Daniela C Moga; Heather Allore
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2018-09-11       Impact factor: 6.053

2.  Delirium in the geriatric unit: proton-pump inhibitors and other risk factors.

Authors:  Iwona Otremba; Krzysztof Wilczyński; Jan Szewieczek
Journal:  Clin Interv Aging       Date:  2016-04-04       Impact factor: 4.458

3.  Comparison of predictors of hip fracture and mortality after hip fracture in community-dwellers with and without Alzheimer's disease - exposure-matched cohort study.

Authors:  Anna-Maija Tolppanen; Heidi Taipale; Antti Tanskanen; Jari Tiihonen; Sirpa Hartikainen
Journal:  BMC Geriatr       Date:  2016-12-01       Impact factor: 3.921

4.  Regional changes in psychotropic use among Finnish persons with newly diagnosed Alzheimer's disease in 2005-2011.

Authors:  Anna-Maija Tolppanen; Ari Voutilainen; Heidi Taipale; Antti Tanskanen; Piia Lavikainen; Marjaana Koponen; Jari Tiihonen; Sirpa Hartikainen
Journal:  PLoS One       Date:  2017-03-09       Impact factor: 3.240

5.  Incidence and Prevalence of Antiepileptic Medication Use in Community-Dwelling Persons with and without Alzheimer's Disease.

Authors:  Tatyana Sarycheva; Heidi Taipale; Piia Lavikainen; Jari Tiihonen; Antti Tanskanen; Sirpa Hartikainen; Anna-Maija Tolppanen
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

  5 in total

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