Literature DB >> 26449825

KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells.

Dexiang Zhang1, Yuedi Dai2, Yuankun Cai1, Tao Suo3, Han Liu3, Yueqi Wang3, Zhijian Cheng4, Houbao Liu5.   

Abstract

Members of the Kruppel-like factor (KLF) family have been considered as the tumor suppressors for their inhibitory effects on cell proliferation. Dysregulation of KLF2, a member of KLF family, has been observed in various cancer types. However, its expression pattern and functions in the pancreatic ductal adenocarcinoma (PDAC) are unknown. In this study, we examined the expression of KLF2 in PDAC clinical samples and evaluated the functions of KLF2 in the progression of PDAC. KLF2 is shown to be downregulated in PDAC clinical samples and overexpression of KLF2 inhibits the growth, migration, and metastasis of PDAC cancer cells. KLF2 interacts with beta-catenin and negatively regulates the beta-catenin/TCF signaling. Taken together, this study suggests the suppressive functions of KLF2 in PDAC.

Entities:  

Keywords:  Beta-catenin/TCF signaling; Cell growth and migration; KLF2; PDAC

Mesh：

Substances：

Year:  2015        PMID： 26449825     DOI： 10.1007/s13277-015-4053-3

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  22 in total

1.  SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.

Authors:  T-P Xu; X-X Liu; R Xia; L Yin; R Kong; W-M Chen; M-D Huang; Y-Q Shu
Journal:  Oncogene       Date:  2015-03-02       Impact factor: 9.867

Review 2.  Emerging roles of Kruppel-like factor 6 and Kruppel-like factor 6 splice variant 1 in ovarian cancer progression and treatment.

Authors:  Analisa DiFeo; Goutham Narla; John A Martignetti
Journal:  Mt Sinai J Med       Date:  2009-12

3.  KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin.

Authors:  Paul M Evans; Xi Chen; Wen Zhang; Chunming Liu
Journal:  Mol Cell Biol       Date:  2009-11-09       Impact factor: 4.272

Review 4.  Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors.

Authors:  J Turner; M Crossley
Journal:  Int J Biochem Cell Biol       Date:  1999-10       Impact factor: 5.085

Review 5.  Targeting Krüppel-like factor 5 (KLF5) for cancer therapy.

Authors:  Yu Gao; Ye Ding; Haiying Chen; Haijun Chen; Jia Zhou
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

6.  Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.

Authors:  Ping Xie; Ying Tang; Shan Shen; Yunyan Wang; Guichun Xing; Yuxin Yin; Fuchu He; Lingqiang Zhang
Journal:  Biochem Biophys Res Commun       Date:  2011-03-05       Impact factor: 3.575

7.  Krüppel-like factor 9 was down-regulated in esophageal squamous cell carcinoma and negatively regulated beta-catenin/TCF signaling.

Authors:  Fan Qiao; Feng Yao; Ling Chen; Chengjun Lu; Yiqian Ni; Wentao Fang; Hai Jin
Journal:  Mol Carcinog       Date:  2015-01-16       Impact factor: 4.784

8.  Krüpel-like factor 8 is a potential prognostic factor for pancreatic cancer.

Authors:  Yingxin Wei; Ge Chen; Lei You; Yupei Zhao
Journal:  Chin Med J (Engl)       Date:  2014       Impact factor: 2.628

9.  Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer.

Authors:  H Taniguchi; F V Jacinto; A Villanueva; A F Fernandez; H Yamamoto; F J Carmona; S Puertas; V E Marquez; Y Shinomura; K Imai; M Esteller
Journal:  Oncogene       Date:  2011-09-05       Impact factor: 9.867

10.  Genomic profiling of tumor initiating prostatospheres.

Authors:  Maria Ana Duhagon; Elaine M Hurt; Jose R Sotelo-Silveira; Xiaohu Zhang; William L Farrar
Journal:  BMC Genomics       Date:  2010-05-25       Impact factor: 3.969
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  13 in total

Review 1.  Inherited pancreatic cancer.

Authors:  Fei Chen; Nicholas J Roberts; Alison P Klein
Journal:  Chin Clin Oncol       Date:  2017-12

Review 2.  SP and KLF Transcription Factors in Digestive Physiology and Diseases.

Authors:  Chang-Kyung Kim; Ping He; Agnieszka B Bialkowska; Vincent W Yang
Journal:  Gastroenterology       Date:  2017-03-30       Impact factor: 22.682

3.  Long non-coding RNA IRAIN suppresses apoptosis and promotes proliferation by binding to LSD1 and EZH2 in pancreatic cancer.

Authors:  Yifan Lian; Juan Wang; Jing Feng; Jie Ding; Zhonghua Ma; Juan Li; Peng Peng; Wei De; Keming Wang
Journal:  Tumour Biol       Date:  2016-09-19

4.  miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family.

Authors:  Cody J Wehrkamp; Sathish Kumar Natarajan; Ashley M Mohr; Mary Anne Phillippi; Justin L Mott
Journal:  RNA Biol       Date:  2018-02-01       Impact factor: 4.652

5.  Methylation of kruppel-like factor 2 (KLF2) associates with its expression and non-small cell lung cancer progression.

Authors:  Wenbin Jiang; Xueqing Xu; Shaoli Deng; Jie Luo; Huan Xu; Chao Wang; Tingting Sun; Guoqin Lei; Fengling Zhang; Cheng Yang; Lin Zhou; Feng Wang; Ming Chen
Journal:  Am J Transl Res       Date:  2017-04-15       Impact factor: 4.060

6.  microRNA-32-5p targets KLF2 to promote gastric cancer by activating PI3K/AKT signaling pathway.

Authors:  Qingqing Wang; Yuan He; Weiqiong Kan; Fucai Li; Xiangjun Ji; Xuewen Wu; Xinyue Wang; Yue Zhang; Jinlian Chen
Journal:  Am J Transl Res       Date:  2019-08-15       Impact factor: 4.060

7.  Long non-coding RNA SNHG15 inhibits P15 and KLF2 expression to promote pancreatic cancer proliferation through EZH2-mediated H3K27me3.

Authors:  Zhonghua Ma; Hesuyuan Huang; Jirong Wang; Yan Zhou; Fuxing Pu; Qinghong Zhao; Peng Peng; Bingqing Hui; Hao Ji; Keming Wang
Journal:  Oncotarget       Date:  2017-08-18

8.  Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling.

Authors:  Chunmei Wang; Liang Li; Qiuhui Duan; Qingqing Wang; Jinlian Chen
Journal:  Oncotarget       Date:  2017-11-01

9.  SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma.

Authors:  Yi Xu; Yue Yao; Xingming Jiang; Xiangyu Zhong; Zhidong Wang; Chunlong Li; Pengcheng Kang; Kaiming Leng; Daolin Ji; Zhenglong Li; Lining Huang; Wei Qin; Yunfu Cui
Journal:  J Exp Clin Cancer Res       Date:  2018-04-11

10.  DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2.

Authors:  Yifan Lian; Jiebin Yang; Yikai Lian; Chuangxing Xiao; Xuezhen Hu; Hongzhi Xu
Journal:  Cancer Commun (Lond)       Date:  2018-10-26
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