Literature DB >> 26448670

Before and After Study of Pharmacists' and Students' Knowledge of Two Novel Antidotes: High-Dose Insulin Euglycemia and Intravenous Fatty Acid Emulsion 20.

Samantha P Jellinek-Cohen1, Amanda Tolento2, Mary Ann Howland3.   

Abstract

PURPOSE: To assess pharmacists' and students' knowledge of high-dose insulin euglycemia (HIE) and intravenous fatty acid emulsion 20% (IFE) and to see whether it improved after an educational intervention.
METHODS: A survey to assess the knowledge about the use of HIE and IFE as antidotes was e-mailed to practicing pharmacists, pharmacy residents, and students prior to and following an educational intervention. Fact sheets on the antidotes were developed in conjunction with the New York City Poison Control Center and were used as the educational intervention in this study. The impact of exposure to the intervention was measured by comparing the number of correct responses per question on the pre- and posttests and the mean pre- and posttest scores using chi-square and t tests, respectively.
RESULTS: Most respondents felt either not at all or only somewhat comfortable with managing a toxicologic emergency. There was a statistically significant difference in mean scores on the pretest and posttest (2.9 vs 5.45; P = .001) and for the number of participants giving correct responses for each question before and after education: 52.4% of respondents answered "I don't know" to the questions prior to education versus 21.2% after education (P < .001). Fewer respondents felt not at all comfortable managing a toxicologic emergency after the educational intervention (42.4 vs 50.3%; P < .001).
CONCLUSION: Pharmacists and students reported little comfort in managing toxicological emergencies in general and have limited baseline knowledge about these agents. Educational interventions can significantly improve knowledge. Prior familiarity with these newer antidotes should reduce delays in their administration in an emergency.

Entities:  

Keywords:  antidotes; fact sheets; knowledge; pharmacists; survey

Year:  2015        PMID: 26448670      PMCID: PMC4589861          DOI: 10.1310/hpj5007-586

Source DB:  PubMed          Journal:  Hosp Pharm        ISSN: 0018-5787


  22 in total

Review 1.  State of the art review: Intravenous fat emulsions: Current applications, safety profile, and clinical implications.

Authors:  Jay M Mirtallo; Joseph F Dasta; Kurt C Kleinschmidt; Joseph Varon
Journal:  Ann Pharmacother       Date:  2010-04       Impact factor: 3.154

Review 2.  Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Authors:  Terry L Vanden Hoek; Laurie J Morrison; Michael Shuster; Michael Donnino; Elizabeth Sinz; Eric J Lavonas; Farida M Jeejeebhoy; Andrea Gabrielli
Journal:  Circulation       Date:  2010-11-02       Impact factor: 29.690

Review 3.  Intravenous fat emulsion: a potential novel antidote.

Authors:  Danielle E Turner-Lawrence; William Kerns Ii
Journal:  J Med Toxicol       Date:  2008-06

Review 4.  ASRA practice advisory on local anesthetic systemic toxicity.

Authors:  Joseph M Neal; Christopher M Bernards; John F Butterworth; Guido Di Gregorio; Kenneth Drasner; Michael R Hejtmanek; Michael F Mulroy; Richard W Rosenquist; Guy L Weinberg
Journal:  Reg Anesth Pain Med       Date:  2010 Mar-Apr       Impact factor: 6.288

5.  Availability of antidotes for the treatment of acute poisoning in Queensland public hospitals.

Authors:  Lisa M Nissen; Kai Hang Wong; Anthea Jones; Darren M Roberts
Journal:  Aust J Rural Health       Date:  2010-04       Impact factor: 1.662

6.  Medication errors associated with the use of ethanol and fomepizole as antidotes for methanol and ethylene glycol poisoning.

Authors:  Katherine J Lepik; Boris G Sobolev; Adrian R Levy; Roy A Purssell; Christopher R Dewitt; Gunnar D Erhardt; Jane L Baker; James R Kennedy; Derek E Daws
Journal:  Clin Toxicol (Phila)       Date:  2011-06       Impact factor: 4.467

7.  Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.

Authors:  Bryan D Hayes; Wendy Klein-Schwartz; Suzanne Doyon
Journal:  Ann Pharmacother       Date:  2008-04-29       Impact factor: 3.154

Review 8.  Hyperinsulinemic euglycemia therapy for verapamil poisoning: a review.

Authors:  Nirav P Patel; Meredith E Pugh; Steven Goldberg; Glenn Eiger
Journal:  Am J Crit Care       Date:  2007-09       Impact factor: 2.228

Review 9.  Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data.

Authors:  W Stephen Waring
Journal:  Expert Rev Clin Pharmacol       Date:  2012-07       Impact factor: 5.045

Review 10.  Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers.

Authors:  Philippe E R Lheureux; Soheil Zahir; Mireille Gris; Anne-Sophie Derrey; Andrea Penaloza
Journal:  Crit Care       Date:  2006-05-22       Impact factor: 9.097

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