AIMS: To evaluate three guidelines for selecting short children for diagnostic workup in a general pediatric clinic. METHODS: All patients (n = 131) aged 3.00-9.99 years who were referred for growth failure to a general pediatric clinic were evaluated for their medical history and growth and examined. All of them underwent the same standardized diagnostic workup. Retrospectively, the criteria for the diagnostic workup from three guidelines (proposed in the Netherlands, Finland and the UK) were applied, and their sensitivity was assessed. A Dutch reference sample (n = 958) was used for calculating population specificity. RESULTS: In 23 patients (17.6%), a pathological cause of their growth failure was found. The sensitivity of the original Dutch, Finnish and British guidelines was 73.9, 78.3 and 56.5% and their specificity 98.5, 83.7 and 95.8%, respectively. When adding recent growth deflection to the Dutch guideline, sensitivity increased to 87%, but specificity decreased markedly (to 87%). CONCLUSION: The proposed cutoff values for height standard deviation score and distance to target height/mid-parental height, as used in the Netherlands and Finland, are effective for population growth monitoring, and superior to the monitoring algorithm in the UK. Growth deflection irrespective of height is an important sign of acquired growth disorders, but its specificity is too low for population screening.
AIMS: To evaluate three guidelines for selecting short children for diagnostic workup in a general pediatric clinic. METHODS: All patients (n = 131) aged 3.00-9.99 years who were referred for growth failure to a general pediatric clinic were evaluated for their medical history and growth and examined. All of them underwent the same standardized diagnostic workup. Retrospectively, the criteria for the diagnostic workup from three guidelines (proposed in the Netherlands, Finland and the UK) were applied, and their sensitivity was assessed. A Dutch reference sample (n = 958) was used for calculating population specificity. RESULTS: In 23 patients (17.6%), a pathological cause of their growth failure was found. The sensitivity of the original Dutch, Finnish and British guidelines was 73.9, 78.3 and 56.5% and their specificity 98.5, 83.7 and 95.8%, respectively. When adding recent growth deflection to the Dutch guideline, sensitivity increased to 87%, but specificity decreased markedly (to 87%). CONCLUSION: The proposed cutoff values for height standard deviation score and distance to target height/mid-parental height, as used in the Netherlands and Finland, are effective for population growth monitoring, and superior to the monitoring algorithm in the UK. Growth deflection irrespective of height is an important sign of acquired growth disorders, but its specificity is too low for population screening.
Authors: Gemma White; Shakira Cosier; Afiya Andrews; Lee Martin; Ruben Willemsen; Martin O Savage; Helen L Storr Journal: BMJ Paediatr Open Date: 2022-07
Authors: Jenny Child; Christine Davies; Katie Frost; Eleanor McDermid; Rachel Pidcock; John Weinman; Martin O. Savage Journal: J Clin Res Pediatr Endocrinol Date: 2019-11-20
Authors: José I. Labarta; Michael B. Ranke; Mohamad Maghnie; David Martin; Laura Guazzarotti; Roland Pfäffle; Ekaterina Koledova; Jan M. Wit Journal: J Clin Res Pediatr Endocrinol Date: 2020-10-02
Authors: Mohamad Maghnie; José I Labarta; Ekaterina Koledova; Tilman R Rohrer Journal: Front Endocrinol (Lausanne) Date: 2018-01-11 Impact factor: 5.555