Johanna Metsälä1, Beata Stach-Lempinen1, Mika Gissler2,3, Johan G Eriksson4,5,6,7, Saila Koivusalo8. 1. Department of Obstetrics and Gynecology, South Karelia Central Hospital, Lappeenranta, Finland. 2. Department of Information, National Institute for Health and Welfare, Helsinki, Finland. 3. Nordic School of Public Health, Gothenburg, Sweden. 4. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. 5. Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland. 6. Folkhälsan Research Centre, Helsinki, Helsingfors Universitet, Helsinki, Finland. 7. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. 8. Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.
Abstract
BACKGROUND: Overweight and obesity are well-known risk factors for several pregnancy-related complications, but the nature of the association between maternal adiposity and these complications has been less studied. The objective of the present study was to examine the shape and the magnitude of the association between maternal prepregnancy body mass index and the risk of gestational diabetes, pre-eclampsia of different severity, gestational hypertension, and obstetric cholestasis among Finnish primiparae women. METHODS: Data on all primiparae women who delivered a singleton newborn in Finland between 2006 and 2010 were identified from the Finnish Medical Birth Register and the Finnish Hospital Discharge Register (n = 119 485). Associations were analysed using restricted cubic spline regression and logistic regression models. RESULTS: There was a nonlinear dose-dependent association between body mass index and the risk of gestational diabetes, pre-eclampsia, and gestational hypertension, and the risk was increased already among normal weight primiparae women. However, in the presence of pre-existing hypertension or diabetes body mass index was not associated with the risk of pre-eclampsia. CONCLUSIONS: Efforts to reduce prepregnancy overweight and obesity need to be intensified, and also, measures to better identify those normal weight women who are at increased risk of gestational diabetes, pre-eclampsia and gestational hypertension should be developed.
BACKGROUND: Overweight and obesity are well-known risk factors for several pregnancy-related complications, but the nature of the association between maternal adiposity and these complications has been less studied. The objective of the present study was to examine the shape and the magnitude of the association between maternal prepregnancy body mass index and the risk of gestational diabetes, pre-eclampsia of different severity, gestational hypertension, and obstetric cholestasis among Finnish primiparae women. METHODS: Data on all primiparae women who delivered a singleton newborn in Finland between 2006 and 2010 were identified from the Finnish Medical Birth Register and the Finnish Hospital Discharge Register (n = 119 485). Associations were analysed using restricted cubic spline regression and logistic regression models. RESULTS: There was a nonlinear dose-dependent association between body mass index and the risk of gestational diabetes, pre-eclampsia, and gestational hypertension, and the risk was increased already among normal weight primiparae women. However, in the presence of pre-existing hypertension or diabetes body mass index was not associated with the risk of pre-eclampsia. CONCLUSIONS: Efforts to reduce prepregnancy overweight and obesity need to be intensified, and also, measures to better identify those normal weight women who are at increased risk of gestational diabetes, pre-eclampsia and gestational hypertension should be developed.
Authors: Wei-Jen Chen; Erin M Davis; Julie A Stoner; Candace Robledo; Jean R Goodman; Tabitha Garwe; Amanda E Janitz; Chao Xu; Jooyeon Hwang; Jennifer D Peck Journal: Chemosphere Date: 2021-02-02 Impact factor: 7.086
Authors: Caroline Ovadia; Alvaro Perdones-Montero; Hei Man Fan; Benjamin H Mullish; Julie A K McDonald; Georgia Papacleovoulou; Annika Wahlström; Marcus Ståhlman; Anastasia Tsakmaki; Louise C D Clarke; Alexandros Sklavounos; Peter H Dixon; Gavin A Bewick; Julian R F Walters; Hanns-Ulrich Marschall; Julian R Marchesi; Catherine Williamson Journal: Sci Rep Date: 2020-03-03 Impact factor: 4.379