David Celorrio1, Xavier Muñoz2, Pilar Amiano3, Miren Dorronsoro3, Luis Bujanda4, María-José Sánchez5, Esther Molina-Montes5, Carmen Navarro6, M Dolores Chirlaque6, José MaríaHuerta6, Eva Ardanaz7, Aurelio Barricarte7, Laudina Rodriguez8, Eric J Duell9, Elizabeth Hijona4, Marta Herreros-Villanueva4, Núria Sala2, Miguel A Alfonso-Sánchez1, Marian M de Pancorbo10. 1. BIOMICs Research Group, 'Lucio Lascaray' Center for Research and Advanced Studies (CIEA), University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain. 2. Molecular Epidemiology Group, Translational Research Laboratory, Catalan Institute of Oncology (IDIBELL), Barcelona, Spain Unit of Nutrition, and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (IDIBELL), Barcelona, Spain. 3. Public Health Division of Gipuzkoa, Department of Health of the Regional Government of the Basque Country, Donostia, Spain BIODonostia Research Institute, San Sebastián, Spain CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain. 4. Departmenet of Gastroenterology, Donostia Hospital-Instituto Biodonostia, University of the Basque Country (UPV/EHU), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), San Sebastian, Spain. 5. CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain Andalusian School of Public Health, Granada, Spain. 6. CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain Department of Epidemiology, Murcia Health Council, Murcia, Spain. 7. CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain Public Health Institute of Navarra, Pamplona, Spain. 8. Public Health and Health Planning Directorate, Asturias, Spain. 9. Unit of Nutrition, and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (IDIBELL), Barcelona, Spain. 10. BIOMICs Research Group, 'Lucio Lascaray' Center for Research and Advanced Studies (CIEA), University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain marian.mdepancorbo@ehu.es.
Abstract
AIMS: To examine the role of genetic and environmental factors in the pathogenesis of alcohol dependence in a Spanish cohort of women and men. METHODS: We analyzed the relationship between 56 genetic variants in 7 genes associated with the dopaminergic reward pathway and excessive alcohol consumption. The study sample (N = 1533, of which 746 were women) consisted of 653 heavy consumers and 880 very low consumers from the Spanish subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. Lifestyle variables were also examined to assess associations between genetic and environmental factors. RESULTS: No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1, DRD3 and COMT. Conversely, some alleles of the 12 SNPs from the DRD2 locus and the 5 from the MAOA locus showed significant associations with excessive alcohol consumption. Namely, rs10891556 (DRD2) proved to be the only SNP positively correlated with excessive alcohol consumption in both sexes. DRD2 rs1800497 and rs877138 were significantly associated in men, whereas DRD2 rs17601612 and rs4936271 and MAOA rs5906898 were associated with excessive alcohol consumption in women. A correspondence analysis provided an overall lifestyle profile of excessive drinkers, who were predominantly men who smoked, had large intakes of meat, small intakes of fruit and vegetables, whose jobs did not require high education levels and who engaged in little physical activity. CONCLUSIONS: It has shown the influence of dopaminergic pathway in the genetics of alcohol dependence with differences between men and women and providing a lifestyle profile of excessive drinkers.
AIMS: To examine the role of genetic and environmental factors in the pathogenesis of alcohol dependence in a Spanish cohort of women and men. METHODS: We analyzed the relationship between 56 genetic variants in 7 genes associated with the dopaminergic reward pathway and excessive alcohol consumption. The study sample (N = 1533, of which 746 were women) consisted of 653 heavy consumers and 880 very low consumers from the Spanish subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. Lifestyle variables were also examined to assess associations between genetic and environmental factors. RESULTS: No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1, DRD3 and COMT. Conversely, some alleles of the 12 SNPs from the DRD2 locus and the 5 from the MAOA locus showed significant associations with excessive alcohol consumption. Namely, rs10891556 (DRD2) proved to be the only SNP positively correlated with excessive alcohol consumption in both sexes. DRD2rs1800497 and rs877138 were significantly associated in men, whereas DRD2rs17601612 and rs4936271 and MAOArs5906898 were associated with excessive alcohol consumption in women. A correspondence analysis provided an overall lifestyle profile of excessive drinkers, who were predominantly men who smoked, had large intakes of meat, small intakes of fruit and vegetables, whose jobs did not require high education levels and who engaged in little physical activity. CONCLUSIONS: It has shown the influence of dopaminergic pathway in the genetics of alcohol dependence with differences between men and women and providing a lifestyle profile of excessive drinkers.
Authors: Ovidiu Dan Iancu; Alex M Colville; Beth Wilmot; Robert Searles; Priscila Darakjian; Christina Zheng; Shannon McWeeney; Sunita Kawane; John C Crabbe; Pamela Metten; Denesa Oberbeck; Robert Hitzemann Journal: Alcohol Clin Exp Res Date: 2018-06-22 Impact factor: 3.455
Authors: Iker Alegria-Lertxundi; Carmelo Aguirre; Luis Bujanda; Francisco Javier Fernández; Francisco Polo; José M Ordovás; M Carmen Etxezarraga; Iñaki Zabalza; Mikel Larzabal; Isabel Portillo; Marian M de Pancorbo; Leire Palencia-Madrid; Ana M Rocandio; Marta Arroyo-Izaga Journal: PLoS One Date: 2019-12-10 Impact factor: 3.240