Literature DB >> 26446651

Limb Lengthening in Patients with Achondroplasia.

Kwang-Won Park1, Rey-an Niño Garcia1, Chastity Amor Rejuso1, Jung-Woo Choi1, Hae-Ryong Song2.   

Abstract

PURPOSE: Although bilateral lower-limb lengthening has been performed on patients with achondroplasia, the outcomes for the tibia and femur in terms of radiographic parameters, clinical results, and complications have not been compared with each other. We proposed 1) to compare the radiological outcomes of femoral and tibial lengthening and 2) to investigate the differences of complications related to lengthening.
MATERIALS AND METHODS: We retrospectively reviewed 28 patients (average age, 14 years 4 months) with achondroplasia who underwent bilateral limb lengthening between 2004 and 2012. All patients first underwent bilateral tibial lengthening, and at 9-48 months (average, 17.8 months) after this procedure, bilateral femoral lengthening was performed. We analyzed the pixel value ratio (PVR) and characteristics of the callus of the lengthened area on serial radiographs. The external fixation index (EFI) and healing index (HI) were computed to compare tibial and femoral lengthening. The complications related to lengthening were assessed.
RESULTS: The average gain in length was 8.4 cm for the femur and 9.8 cm for the tibia. The PVR, EFI, and HI of the tibia were significantly better than those of the femur. Fewer complications were found during the lengthening of the tibia than during the lengthening of the femur.
CONCLUSION: Tibial lengthening had a significantly lower complication rate and a higher callus formation rate than femoral lengthening. Our findings suggest that bilateral limb lengthening (tibia, followed by femur) remains a reasonable option; however, we should be more cautious when performing femoral lengthening in selected patients.

Entities:  

Keywords:  Achondroplasia; bone lengthening

Mesh:

Year:  2015        PMID: 26446651      PMCID: PMC4630057          DOI: 10.3349/ymj.2015.56.6.1656

Source DB:  PubMed          Journal:  Yonsei Med J        ISSN: 0513-5796            Impact factor:   2.759


  31 in total

1.  Attempted limb lengthenings beyond twenty percent of the initial bone length: results and complications.

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4.  [Bilateral simultaneous limb lengthening of patients with short stature using the Ilizarov method].

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Authors:  Tim Takken; Monique W M van Bergen; Ralph J B Sakkers; Paul J M Helders; Raoul H H Engelbert
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8.  Equinus deformity during tibial lengthening with ankle orthoses for equalization of leg-length discrepancies.

Authors:  Akira Yoshino; Masato Takao; Ken Innami; Takashi Matsushita
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9.  Complications of limb lengthening. A learning curve.

Authors:  M T Dahl; B Gulli; T Berg
Journal:  Clin Orthop Relat Res       Date:  1994-04       Impact factor: 4.176

10.  Value of measuring bone density serial changes on a picture archiving and communication systems (PACS) monitor in distraction osteogenesis.

Authors:  Jong Sup Shim; Kwang Hoon Chung; Joong Mo Ahn
Journal:  Orthopedics       Date:  2002-11       Impact factor: 1.390

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2.  Improvement of the sagittal alignment of the spine in patients with achondroplasia after subtrochanteric femoral lengthening.

Authors:  Rosa M Egea-Gámez; María Galán-Olleros; Javier Alonso-Hernández; Carlos Miranda-Gorozarri; Ignacio Martínez-Caballero; Ángel Palazón-Quevedo; Rafael González-Díaz
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Review 3.  Exploring the Ethics of Stature Lengthening as Treatment for Height Dysphoria.

Authors:  Richard C Lee; Mark Aulisio; Raymond W Liu
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4.  Sustained hip flexion contracture after femoral lengthening in patients with achondroplasia.

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Journal:  BMC Musculoskelet Disord       Date:  2018-11-29       Impact factor: 2.362

5.  Whole-body and segmental analysis of body composition in adult males with achondroplasia using dual X-ray absorptiometry.

Authors:  David Sims; Gladys Onambélé-Pearson; Adrian Burden; Carl Payton; Christopher Morse
Journal:  PLoS One       Date:  2019-03-19       Impact factor: 3.240

6.  Surgical Results of Limb Lengthening at the Femur, Tibia, and Humerus in Patients with Achondroplasia.

Authors:  Kyung Rae Ko; Jong Sup Shim; Chae Hoon Chung; Joo Hwan Kim
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7.  Clinical Practice Guidelines for Achondroplasia.

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8.  Surgical Treatment of an Infected Nonunion of the Middle Third of the Femur Associated with Femoral Shortening in a Hemophilia Patient.

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9.  The Oxygen Consumption and Metabolic Cost of Walking and Running in Adults With Achondroplasia.

Authors:  David T Sims; Gladys L Onambélé-Pearson; Adrian Burden; Carl Payton; Christopher I Morse
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Review 10.  Extensive Limb Lengthening for Achondroplasia and Hypochondroplasia.

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