Literature DB >> 26445508

Making Biological Sense of GWAS Data: Lessons from the FTO Locus.

Mark A Herman1, Evan D Rosen2.   

Abstract

GWAS have yielded many candidate loci for complex diseases like obesity, but interpreting the biological context of these findings has been difficult. Claussnitzer et al. (2015) use a sophisticated combination of bioinformatic and experimental approaches to address this bottleneck for variants in the FTO locus that associate with obesity.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26445508     DOI： 10.1016/j.cmet.2015.09.018

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  8 in total

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Authors:  Winyoo Chowanadisai; Matthew D Hart; Morgan D Strong; David M Graham; Robert B Rucker; Brenda J Smith; Carl L Keen; Mark A Messerli
Journal:  Adv Nutr       Date:  2020-07-01       Impact factor: 8.701

2.  Translating Polygenic Analysis for Prevention: From Who to How.

Authors:  Daniel W Belsky
Journal:  Circ Cardiovasc Genet       Date:  2017-06

3.  FTO haplotyping underlines high obesity risk for European populations.

Authors:  Vladimir Babenko; Roman Babenko; Junaid Gamieldien; Arcady Markel
Journal:  BMC Med Genomics       Date:  2019-03-13       Impact factor: 3.063

4.  Strategies for Pathway Analysis Using GWAS and WGS Data.

Authors:  Marquitta J White; Brian L Yaspan; Olivia J Veatch; Pagé Goddard; Oona S Risse-Adams; Maria G Contreras
Journal:  Curr Protoc Hum Genet       Date:  2018-11-02

5.  Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response.

Authors:  Joe Eun Son; Zhengchao Dou; Kyoung-Han Kim; Siyi Wanggou; Vincent Su Bin Cha; Rong Mo; Xiaoyun Zhang; Xinyu Chen; Troy Ketela; Xuejun Li; Xi Huang; Chi-Chung Hui
Journal:  Nat Metab       Date:  2021-04-15

6.  Body mass index and psychiatric disorders: a Mendelian randomization study.

Authors:  Fernando Pires Hartwig; Jack Bowden; Christian Loret de Mola; Luciana Tovo-Rodrigues; George Davey Smith; Bernardo Lessa Horta
Journal:  Sci Rep       Date:  2016-09-07       Impact factor: 4.379

7.  CDK5 Regulatory Subunit-Associated Protein 1-like 1 Negatively Regulates Adipocyte Differentiation through Activation of Wnt Signaling Pathway.

Authors:  Kazumi Take; Hironori Waki; Wei Sun; Takahito Wada; Jing Yu; Masahiro Nakamura; Tomohisa Aoyama; Toshimasa Yamauchi; Takashi Kadowaki
Journal:  Sci Rep       Date:  2017-08-04       Impact factor: 4.379

8.  Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients.

Authors:  Anastasiia S Boiko; Ivan V Pozhidaev; Diana Z Paderina; Anna V Bocharova; Irina A Mednova; Olga Yu Fedorenko; Elena G Kornetova; Anton J M Loonen; Arkadiy V Semke; Nikolay A Bokhan; Svetlana A Ivanova
Journal:  Pharmgenomics Pers Med       Date:  2021-09-07
  8 in total

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