| Literature DB >> 26444098 |
Jiewei Wu1, Chunping Tang1, Sheng Yao1, Lei Zhang, Changqiang Ke1, Linyin Feng, Ge Lin1,2, Yang Ye1,3.
Abstract
Twelve new inositol derivatives, classified into myoinositol (1-6) and l-inositol (10-15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed anti-inflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC50 values ranging from 7 to 23 μM.Entities:
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Year: 2015 PMID： 26444098 DOI： 10.1021/acs.jnatprod.5b00135
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050