Literature DB >> 26444094

Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson's Disease?

Alison J Yarnall1, Rachael A Lawson1, Gordon W Duncan1, David P Breen2, Tien K Khoo1, David Brooks3, Roger A Barker2, John-Paul Taylor1, David J Burn1.   

Abstract

We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores were not significantly different. Cognitive scores did not differ in PD participants taking medications with anticholinergic activity compared to those who were not. Low overall ADS scores due to increased awareness of adverse effects of medications and brevity of follow-up are potential explanations.

Entities:  

Keywords:  Parkinson disease; amyloid; anticholinergics; dementia; mild cognitive impairment

Mesh：

Substances：

Year:  2015        PMID： 26444094     DOI： 10.3233/JPD-150664

Source DB:  PubMed          Journal:  J Parkinsons Dis        ISSN： 1877-7171            Impact factor:   5.568


  8 in total

Review 1.  Assessment and Management of Neuropsychiatric Symptoms in Parkinson's Disease.

Authors:  Christoph Mueller; Anto P Rajkumar; Yi Min Wan; Latha Velayudhan; Dominic Ffytche; Kallol Ray Chaudhuri; Dag Aarsland
Journal:  CNS Drugs       Date:  2018-07       Impact factor: 5.749

2.  Anticholinergics May Carry Significant Cognitive and Gait Burden in Parkinson's Disease.

Authors:  Roopa Rajan; Arti Saini; Bhawna Verma; Nishu Choudhary; Anu Gupta; Venugopalan Y Vishnu; Rohit Bhatia; Mamta B Singh; Achal K Srivastava; Madakasira Vasantha Padma Srivastava
Journal:  Mov Disord Clin Pract       Date:  2020-08-29

Review 3.  Antimuscarinic Anticholinergic Medications in Parkinson Disease: To Prescribe or Deprescribe?

Authors:  Matthew J Barrett; Lana Sargent; Huma Nawaz; Daniel Weintraub; Elvin T Price; Allison W Willis
Journal:  Mov Disord Clin Pract       Date:  2021-10-08

4.  Anticholinergic drugs and incident dementia, mild cognitive impairment and cognitive decline: a meta-analysis.

Authors:  Nina T Pieper; Carlota M Grossi; Wei-Yee Chan; Yoon K Loke; George M Savva; Clara Haroulis; Nicholas Steel; Chris Fox; Ian D Maidment; Antony J Arthur; Phyo K Myint; Toby O Smith; Louise Robinson; Fiona E Matthews; Carol Brayne; Kathryn Richardson
Journal:  Age Ageing       Date:  2020-10-23       Impact factor: 10.668

5.  Gait-Related Metabolic Covariance Networks at Rest in Parkinson's Disease.

Authors:  Hilmar P Sigurdsson; Alison J Yarnall; Brook Galna; Sue Lord; Lisa Alcock; Rachael A Lawson; Sean J Colloby; Michael J Firbank; John-Paul Taylor; Nicola Pavese; David J Brooks; John T O'Brien; David J Burn; Lynn Rochester
Journal:  Mov Disord       Date:  2022-03-14       Impact factor: 9.698

6.  Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome.

Authors:  Martin Taylor-Rowan; Sophie Edwards; Anna H Noel-Storr; Jenny McCleery; Phyo K Myint; Roy Soiza; Carrie Stewart; Yoon Kong Loke; Terry J Quinn
Journal:  Cochrane Database Syst Rev       Date:  2021-05-05

7.  Associations between Anticholinergic Burden and Adverse Health Outcomes in Parkinson Disease.

Authors:  James A G Crispo; Allison W Willis; Dylan P Thibault; Yannick Fortin; Harlen D Hays; Douglas S McNair; Lise M Bjerre; Dafna E Kohen; Santiago Perez-Lloret; Donald R Mattison; Daniel Krewski
Journal:  PLoS One       Date:  2016-03-03       Impact factor: 3.240

Review 8.  Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review.

Authors:  Angela Lisibach; Valérie Benelli; Marco Giacomo Ceppi; Karin Waldner-Knogler; Chantal Csajka; Monika Lutters
Journal:  Eur J Clin Pharmacol       Date:  2020-10-03       Impact factor: 2.953
  8 in total

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