Literature DB >> 26443703

Proteostasis trumps YAP in colon cancer.

Tony Avril1, Eric Chevet2.   

Abstract

In this issue of Science Signaling, Zhang et al. find a new role for verteporfin in the control of colorectal cancer progression through the selective induction of proteotoxicity rather than through inhibition of the transcription cofactor YAP. The study further documents the potential strategy of targeting proteostasis to kill cancer cells.
Copyright © 2015, American Association for the Advancement of Science.

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Year:  2015        PMID: 26443703     DOI: 10.1126/scisignal.aad3123

Source DB:  PubMed          Journal:  Sci Signal        ISSN: 1945-0877            Impact factor:   8.192


  2 in total

1.  CIZ1 interacts with YAP and activates its transcriptional activity in hepatocellular carcinoma cells.

Authors:  Liu Lei; Jinsheng Wu; Dianhua Gu; Hui Liu; Shaochuang Wang
Journal:  Tumour Biol       Date:  2016-02-23

2.  Clinical implications of the Hippo-YAP pathway in multiple cancer contexts.

Authors:  Han-Byul Kim; Seung-Jae Myung
Journal:  BMB Rep       Date:  2018-03       Impact factor: 4.778

  2 in total

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