Literature DB >> 26443264

Adherence to Antiretroviral Therapy Among Children Living with HIV in South India.

K Mehta1, M L Ekstrand2,3, E Heylen2, G N Sanjeeva4, A Shet5,6.   

Abstract

Adherence to ART, fundamental to treatment success, has been poorly studied in India. Caregivers of children attending HIV clinics in southern India were interviewed using structured questionnaires. Adherence was assessed using a visual analogue scale representing past-month adherence and treatment interruptions >48 h during the past 3 months. Clinical features, correlates of adherence and HIV-1 viral-load were documented. Based on caregiver reports, 90.9 % of the children were optimally adherent. In multivariable analysis, experiencing ART-related adverse effects was significantly associated with suboptimal adherence (p = 0.01). The proportion of children who experienced virological failure was 16.5 %. Virological failure was not linked to suboptimal adherence. Factors influencing virological failure included running out of medications (p = 0.002) and the child refusing to take medications (p = 0.01). Inclusion of drugs with better safety profiles and improved access to care could further enhance outcomes.

Entities:  

Keywords:  Adherence; Antiretroviral therapy; Children; HIV; Virological failure

Mesh：

Substances：

Year:  2016        PMID： 26443264      PMCID： PMC5472452          DOI： 10.1007/s10461-015-1207-7

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  31 in total

1.  Suboptimal adherence associated with virological failure and resistance mutations to first-line highly active antiretroviral therapy (HAART) in Bangalore, India.

Authors:  Maria L Ekstrand; Anita Shet; Sara Chandy; Girija Singh; Ranjani Shamsundar; Vidya Madhavan; Shanmugam Saravanan; Elsa Heylen; Nagalingeswaran Kumarasamy
Journal:  Int Health       Date:  2011-03       Impact factor: 2.473

2.  Assessment of ART centres in India: client perspectives.

Authors:  Ruchi Sogarwal; Damodar Bachani
Journal:  J Indian Med Assoc       Date:  2009-05

3.  Barriers to HAART adherence among human immunodeficiency virus-infected adolescents.

Authors:  Debra A Murphy; Moussa Sarr; Stephen J Durako; Anna-Barbara Moscicki; Craig M Wilson; Larry R Muenz
Journal:  Arch Pediatr Adolesc Med       Date:  2003-03

4.  Clinical outcomes improve with highly active antiretroviral therapy in vertically HIV type-1-infected children.

Authors:  Salvador Resino; Rosa Resino; José Maria Bellón; Dariela Micheloud; Maria Dolores Gurbindo Gutiérrez; Maria Isabel de José; José Tomás Ramos; Pablo Martín Fontelos; Luis Ciria; Maria Angeles Muñoz-Fernández
Journal:  Clin Infect Dis       Date:  2006-06-09       Impact factor: 9.079

5.  Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infection.

Authors:  Russell B Van Dyke; Sophia Lee; George M Johnson; Andrew Wiznia; Kathleen Mohan; Kenneth Stanley; Edward V Morse; Paul A Krogstad; Sharon Nachman
Journal:  Pediatrics       Date:  2002-04       Impact factor: 7.124

6.  Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection: a multicentre, national study.

Authors:  V Giacomet; F Albano; F Starace; A de Franciscis; C Giaquinto; G Castelli Gattinara; E Bruzzese; C Gabiano; L Galli; A Viganò; D Caselli; A Guarino
Journal:  Acta Paediatr       Date:  2003-12       Impact factor: 2.299

7.  Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale.

Authors:  Thomas P Giordano; David Guzman; Richard Clark; Edwin D Charlebois; David R Bangsberg
Journal:  HIV Clin Trials       Date:  2004 Mar-Apr

8.  Determinants of virologic and immunologic outcomes in chronically HIV-infected subjects undergoing repeated treatment interruptions: the Istituto Superiore di Sanita-Pulsed Antiretroviral Therapy (ISS-PART) study.

Authors:  Lucia Palmisano; Marina Giuliano; Raffaella Bucciardini; Vincenzo Fragola; Mauro Andreotti; Clementina Galluzzo; Maria F Pirillo; Liliana E Weimer; Romano Arcieri; Elena A P Germinario; Roberta Amici; Maria Grazia Mancini; Antonella d'Arminio Monforte; Francesco Castelli; Pietro Caramello; Stefano Vella
Journal:  J Acquir Immune Defic Syndr       Date:  2007-09-01       Impact factor: 3.731

Review 9.  Adherence to antiretroviral therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management.

Authors:  Jane M Simoni; Arianna Montgomery; Erin Martin; Michelle New; Penelope A Demas; Sohail Rana
Journal:  Pediatrics       Date:  2007-05-28       Impact factor: 7.124

10.  Risk factors for virological failure and subtherapeutic antiretroviral drug concentrations in HIV-positive adults treated in rural northwestern Uganda.

Authors:  Laurence Ahoua; Gunar Guenther; Loretxu Pinoges; Paul Anguzu; Marie-Laure Chaix; Clotilde Le Tiec; Suna Balkan; David Olson; Charles Olaro; Mar Pujades-Rodríguez
Journal:  BMC Infect Dis       Date:  2009-06-03       Impact factor: 3.090
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  7 in total

1.  Perspectives on disclosure among children living with HIV in India.

Authors:  Kayur Mehta; Maria L Ekstrand; Elsa Heylen; G N Sanjeeva; Anita Shet
Journal:  Child Youth Serv Rev       Date:  2016-11-17

2.  Viral suppression among children and their caregivers living with HIV in western Kenya.

Authors:  John M Humphrey; Becky L Genberg; Alfred Keter; Beverly Musick; Edith Apondi; Adrian Gardner; Joseph W Hogan; Kara Wools-Kaloustian
Journal:  J Int AIDS Soc       Date:  2019-04       Impact factor: 6.707

3.  Level of Adherence and Associated Factors Among HIV-Infected Patients on Antiretroviral Therapy in Northern Ethiopia: Retrospective Analysis.

Authors:  Abraham Aregay Desta; Kibriti Mehari Kidane; Ataklti Gebretsadik Woldegebriel; Kiros Fenta Ajemu; Asfawosen Aregay Berhe; Degnesh Negash Zgita; Letebrhan Weldemhret Teweldemedhn; Lemlem Legesse Woldegebriel; Nega Mamo Bezabih; Tewolde Wubayehu Woldearegay
Journal:  Patient Prefer Adherence       Date:  2020-09-03       Impact factor: 2.711

4.  Clinical, immunologic and virologic outcomes of children and adolescents receiving second line anti-retroviral therapy in two referral hospitals in Addis Ababa, Ethiopia.

Authors:  Endashaw Tekliye; Tinsae Alemayehu; Tigist Bacha
Journal:  PLoS One       Date:  2021-03-30       Impact factor: 3.240

5.  Determinants of Virological Failure Among HIV-Infected Children on First-Line Antiretroviral Therapy in West Gojjam Zone, Amhara Region, Ethiopia.

Authors:  Awoke Shumetie; Nurilign Abebe Moges; Muluken Teshome; Getnet Gedif
Journal:  HIV AIDS (Auckl)       Date:  2021-12-14

6.  Risky behaviours and their correlates among adolescents living with HIV in sub-Saharan Africa: a systematic review.

Authors:  Maggie Zgambo; Fatch Welcome Kalembo; Balwani Chingatichifwe Mbakaya
Journal:  Reprod Health       Date:  2018-10-24       Impact factor: 3.223

Review 7.  Adherence to Highly Active Antiretroviral Therapy Among Children in Ethiopia: A Systematic Review and Meta-analysis.

Authors:  Aklilu Endalamaw; Nega Tezera; Setegn Eshetie; Sintayehu Ambachew; Tesfa Dejenie Habtewold
Journal:  AIDS Behav       Date:  2018-08
  7 in total

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