Literature DB >> 26443092

A 75-year-old woman with acquired haemophilia disguised by warfarin treatment.

Sarah Lawless1, Gary Benson2.   

Abstract

Acquired haemophilia is a rare coagulation disorder more commonly seen in elderly patients. Diagnosis and effective treatment can be delayed if patients are on warfarin treatment, as the bleeding symptoms may be erroneously attributed to this agent. We present a case report of a 75-year-old woman whose unexplained, severe and persistent bleeding was treated with surgical decompression and plasma transfusions, an appropriate management based on the assumption that warfarin was the cause of the bleeding. It was only when the patient's international normalised ratio returned to normal that a persistent abnormal activated partial thromboplastin time was noted. This delayed the correct diagnosis and treatment. Awareness of acquired haemophilia as a possible cause of sudden bleeding should be encouraged, and the wider dissemination of any relevant experience of similar cases would also be welcome. 2015 BMJ Publishing Group Ltd.

Entities:  

Mesh:

Substances:

Year:  2015        PMID: 26443092      PMCID: PMC4600821          DOI: 10.1136/bcr-2015-211254

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

Review 1.  Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors.

Authors:  Julio Delgado; Victor Jimenez-Yuste; Fernando Hernandez-Navarro; Ana Villar
Journal:  Br J Haematol       Date:  2003-04       Impact factor: 6.998

2.  Acquired haemophilia masked by warfarin therapy.

Authors:  C M Vadikolia; A Riddell; S Brooks; T T Yee; S Brown; C Lee
Journal:  Int J Lab Hematol       Date:  2007-02       Impact factor: 2.877

3.  Diagnosis and management of acquired coagulation inhibitors: a guideline from UKHCDO.

Authors:  Peter W Collins; Elizabeth Chalmers; Daniel Hart; Ian Jennings; Ri Liesner; Savita Rangarajan; Kate Talks; Michael Williams; Charles R M Hay
Journal:  Br J Haematol       Date:  2013-07-25       Impact factor: 6.998

Review 4.  Acquired hemophilia masked by warfarin therapy.

Authors:  R Kantor; H Mayan; L Puritz; D Varon; Z Farfel
Journal:  Am J Med Sci       Date:  2000-03       Impact factor: 2.378

5.  Effect of warfarin on the activated partial thromboplastin time.

Authors:  V M Hauser; S L Rozek
Journal:  Drug Intell Clin Pharm       Date:  1986-12

6.  Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).

Authors:  P Knoebl; P Marco; F Baudo; P Collins; A Huth-Kühne; L Nemes; F Pellegrini; L Tengborn; H Lévesque
Journal:  J Thromb Haemost       Date:  2012-04       Impact factor: 5.824

7.  Acquired hemophilia masked by warfarin therapy: report on two cases.

Authors:  Bertil Uggla; Olle Linder; Sam Schulman
Journal:  Blood Coagul Fibrinolysis       Date:  2003-12       Impact factor: 1.276

8.  Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls.

Authors:  A Pavlova; A Diaz-Lacava; H Zeitler; J Satoguina; B Niemann; M Krause; I Scharrer; A Hoerauf; T Wienker; J Oldenburg
Journal:  Haemophilia       Date:  2007-12-10       Impact factor: 4.287

  8 in total
  1 in total

1.  Acquired Hemophilia A May Be Associated with Ticagrelor Therapy in a 52-Year-Old Man After a Recent Percutaneous Transluminal Coronary Angioplasty.

Authors:  Paola Pasquino; Roberto Canaparo; Tiziana Capello; Barbara Deorsola; Laura Perazzolo; Claudio Marengo; Loredana Serpe
Journal:  Clin Med Insights Case Rep       Date:  2016-09-13
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.