Zhaoke Wu1, Ting Wang2, Shenshen Zhu1, Ling Li3. 1. a Department of Gerontology , The Second Affiliated Hospital of Zhengzhou University at Zhengzhou , Zhengzhou , China. 2. b Department of Gerontology , Shanxi Provincial People's Hospital at Xi'an , Xi'an , China. 3. c Department of Cardiology , The First Affiliated Hospital of Zhengzhou University at Zhengzhou , Zhengzhou , China.
Abstract
OBJECTIVES: Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease. DESIGN: We investigated the effect of 0.5 μg vitamin D3 per day in a randomized, placebo-controlled, double-blind study in 90 stable coronary artery disease patients residing in Beijing. Coronary angiography was performed before and after 6 months of treatment that took place between January and June. 25-Hydroxyvitamin D was measured by chemiluminescence assay. Coronary artery disease severity was assessed by using the SYNTAX scores. RESULTS: In vitamin D supplementation group, there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (19.9 ± 9.8 ng/ml) to 6 months (35.8 ± 12.1 ng/ml; p < 0.001). At 6 months, the primary end point, a difference in the fall of SYNTAX score between the groups was -2.5 (95% CI -5.1 to -0.5; p < 0.001) under intention to treat analysis. Compared with the control group, patients treated with vitamin D3 also had greater decreases in high sensitivity C-reactive protein and renin-angiotensin system activity (p < 0.05). CONCLUSIONS:Vitamin D supplementation has beneficial effects on coronary artery disease; it can be an adjuvant therapy for patients with coronary artery disease.
RCT Entities:
OBJECTIVES: Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease. DESIGN: We investigated the effect of 0.5 μg vitamin D3 per day in a randomized, placebo-controlled, double-blind study in 90 stable coronary artery diseasepatients residing in Beijing. Coronary angiography was performed before and after 6 months of treatment that took place between January and June. 25-Hydroxyvitamin D was measured by chemiluminescence assay. Coronary artery disease severity was assessed by using the SYNTAX scores. RESULTS: In vitamin D supplementation group, there was a significant increase in mean 25-hydroxyvitamin D levels from baseline (19.9 ± 9.8 ng/ml) to 6 months (35.8 ± 12.1 ng/ml; p < 0.001). At 6 months, the primary end point, a difference in the fall of SYNTAX score between the groups was -2.5 (95% CI -5.1 to -0.5; p < 0.001) under intention to treat analysis. Compared with the control group, patients treated with vitamin D3 also had greater decreases in high sensitivity C-reactive protein and renin-angiotensin system activity (p < 0.05). CONCLUSIONS:Vitamin D supplementation has beneficial effects on coronary artery disease; it can be an adjuvant therapy for patients with coronary artery disease.
Authors: Fernando de la Guía-Galipienso; María Martínez-Ferran; Néstor Vallecillo; Carl J Lavie; Fabian Sanchis-Gomar; Helios Pareja-Galeano Journal: Clin Nutr Date: 2020-12-29 Impact factor: 7.324
Authors: Armin Zittermann; Jana B Ernst; Sylvana Prokop; Uwe Fuchs; Jens Dreier; Joachim Kuhn; Cornelius Knabbe; Jochen Börgermann; Heiner K Berthold; Stefan Pilz; Ioanna Gouni-Berthold; Jan F Gummert Journal: Int J Endocrinol Date: 2018-07-03 Impact factor: 3.257