Aisha Qamar1, Asma Siddiqui2, Hemant Kumar3. 1. Department of Anatomy, Bahria University Medical and Dental College, Karachi. 2. Department of Anatomy, Fatima Jinnah Dental College, Karachi. 3. Department of Anatomy, Hamdard College of Medicine and Dentistry, Hamdard University, Karachi.
Abstract
OBJECTIVE: To observe the effect of fresh garlic on high-fat-diet-induced fatty liver changes. METHODS: The experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from October to November 2008, and comprised adult albino rats weighing 200-240g each. The rats were divided into 5 groups according to dietary regimen for eight weeks each. Group A received control diet; Group B received high saturated fat diet; Group C received high unsaturated fat diet; Group D received high saturated fat diet with fresh garlic; and Group E received high unsaturated fat diet with garlic for 8 weeks. Liver tissue slides were stained with Oil red-O and haematoxylin and Periodic acid-Schiff-haematoxylin. RESULTS: The 50 rats in the study were divided into five groups of 10(20%) each. There was marked deposition of fat in hepatocyte along with marked decrease in glycogen content in liver of rats in Groups B and C, with Group B showing more marked changes. The changes in fat and glycogen content were reversed and ameliorated close to Group A in rats belonging to Groups D and E. CONCLUSIONS: Fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats.
OBJECTIVE: To observe the effect of fresh garlic on high-fat-diet-induced fatty liver changes. METHODS: The experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi, from October to November 2008, and comprised adult albino rats weighing 200-240g each. The rats were divided into 5 groups according to dietary regimen for eight weeks each. Group A received control diet; Group B received high saturated fat diet; Group C received high unsaturated fat diet; Group D received high saturated fat diet with fresh garlic; and Group E received high unsaturated fat diet with garlic for 8 weeks. Liver tissue slides were stained with Oil red-O and haematoxylin and Periodic acid-Schiff-haematoxylin. RESULTS: The 50 rats in the study were divided into five groups of 10(20%) each. There was marked deposition of fat in hepatocyte along with marked decrease in glycogen content in liver of rats in Groups B and C, with Group B showing more marked changes. The changes in fat and glycogen content were reversed and ameliorated close to Group A in rats belonging to Groups D and E. CONCLUSIONS: Fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats.
Authors: Yawen Zeng; Yuping Li; Jiazhen Yang; Xiaoying Pu; Juan Du; Xiaomeng Yang; Tao Yang; Shuming Yang Journal: Evid Based Complement Alternat Med Date: 2017-02-05 Impact factor: 2.629